骨髓瘤细胞系MM1共刺激分子的差异表达模式。R

A. De la Cruz-Rosas , A. Martínez-Tovar , C. Ramos-Peñafiel , J. Collazo-Jaloma , I. Olarte-Carrillo
{"title":"骨髓瘤细胞系MM1共刺激分子的差异表达模式。R","authors":"A. De la Cruz-Rosas ,&nbsp;A. Martínez-Tovar ,&nbsp;C. Ramos-Peñafiel ,&nbsp;J. Collazo-Jaloma ,&nbsp;I. Olarte-Carrillo","doi":"10.1016/j.hgmx.2016.08.005","DOIUrl":null,"url":null,"abstract":"<div><p>T cells constantly recognise and eliminate circulating tumour cells. They require two signals in order to be activated: antigen presentation via TCR, and costimulatory interaction with different surface molecules of the B7 family, which may either enhance or attenuate immune response. In several cancers these molecules are deregulated, thereby promoting immune escape and the settlement or migration of cancer cells. In multiple myeloma, the expression of B7 co-inhibitory molecules and their relationship to disease progression have been identified. The MM1.R cell line is a useful cellular model for studying the progression of this disease, and therefore an analysis of the pattern of expression in this cell line helps to cast light on the immune status of this disease. Using a real-time PCR (quantitative RT-PCR) assay, we found that the main molecules expressed were those with an inhibitory function (B7-H1, B7-H3 and B7-H4), which suggests a high level of immune inhibition by these cells.</p></div>","PeriodicalId":31559,"journal":{"name":"Revista Medica del Hospital General de Mexico","volume":"81 4","pages":"Pages 197-202"},"PeriodicalIF":0.0000,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hgmx.2016.08.005","citationCount":"1","resultStr":"{\"title\":\"Pattern of differential expression of costimulatory molecules in myeloma cell line MM1.R\",\"authors\":\"A. De la Cruz-Rosas ,&nbsp;A. Martínez-Tovar ,&nbsp;C. Ramos-Peñafiel ,&nbsp;J. Collazo-Jaloma ,&nbsp;I. Olarte-Carrillo\",\"doi\":\"10.1016/j.hgmx.2016.08.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>T cells constantly recognise and eliminate circulating tumour cells. They require two signals in order to be activated: antigen presentation via TCR, and costimulatory interaction with different surface molecules of the B7 family, which may either enhance or attenuate immune response. In several cancers these molecules are deregulated, thereby promoting immune escape and the settlement or migration of cancer cells. In multiple myeloma, the expression of B7 co-inhibitory molecules and their relationship to disease progression have been identified. The MM1.R cell line is a useful cellular model for studying the progression of this disease, and therefore an analysis of the pattern of expression in this cell line helps to cast light on the immune status of this disease. Using a real-time PCR (quantitative RT-PCR) assay, we found that the main molecules expressed were those with an inhibitory function (B7-H1, B7-H3 and B7-H4), which suggests a high level of immune inhibition by these cells.</p></div>\",\"PeriodicalId\":31559,\"journal\":{\"name\":\"Revista Medica del Hospital General de Mexico\",\"volume\":\"81 4\",\"pages\":\"Pages 197-202\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.hgmx.2016.08.005\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Medica del Hospital General de Mexico\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0185106316300865\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Medica del Hospital General de Mexico","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0185106316300865","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

T细胞不断识别并清除循环中的肿瘤细胞。它们需要两个信号才能被激活:通过TCR呈递抗原,以及与B7家族不同表面分子的共刺激相互作用,这可能增强或减弱免疫应答。在一些癌症中,这些分子被解除调控,从而促进免疫逃逸和癌细胞的定居或迁移。在多发性骨髓瘤中,B7共抑制分子的表达及其与疾病进展的关系已被确定。MM1。R细胞系是研究该疾病进展的有用细胞模型,因此分析该细胞系的表达模式有助于阐明该疾病的免疫状态。通过实时荧光定量PCR (quantitative RT-PCR)检测,我们发现主要表达的是具有抑制功能的分子(B7-H1, B7-H3和B7-H4),这表明这些细胞具有高度的免疫抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pattern of differential expression of costimulatory molecules in myeloma cell line MM1.R

T cells constantly recognise and eliminate circulating tumour cells. They require two signals in order to be activated: antigen presentation via TCR, and costimulatory interaction with different surface molecules of the B7 family, which may either enhance or attenuate immune response. In several cancers these molecules are deregulated, thereby promoting immune escape and the settlement or migration of cancer cells. In multiple myeloma, the expression of B7 co-inhibitory molecules and their relationship to disease progression have been identified. The MM1.R cell line is a useful cellular model for studying the progression of this disease, and therefore an analysis of the pattern of expression in this cell line helps to cast light on the immune status of this disease. Using a real-time PCR (quantitative RT-PCR) assay, we found that the main molecules expressed were those with an inhibitory function (B7-H1, B7-H3 and B7-H4), which suggests a high level of immune inhibition by these cells.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
25
审稿时长
20 weeks
期刊介绍: The Medical Journal of the Hospital General de Mexico is the official organ of the Medical Society of the Hospital General de Mexico. The journal accepts articles in Spanish or in English on the field of hospital medicine. The journal publishes original articles, clinical cases, reviews articles, history notes, issues on medical education, short communications and editorials at the invitation of the Society. All articles are double blind peer reviewed by at least 2 reviewers and finally classified as accepted or rejected by the Editorial Board.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信