两种乳腺细胞系对化疗药物的DNA损伤反应的通路中心分析

Q4 Biochemistry, Genetics and Molecular Biology

EuPA Open Proteomics Pub Date : 2015-09-01 DOI:10.1016/j.euprot.2015.05.002

Linn Antberg , Paolo Cifani , Fredrik Levander , Peter James

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引用次数: 6

摘要

在两种乳腺癌细胞系中研究了烷基化和DNA拓扑异构酶抑制对DNA损伤的反应。我们展示了霰弹枪和靶向、以途径为中心的方法的数据，以突出细胞系中不同的DNA修复途径调制以及与活力和DNA损伤分析的相关性。这种类型的集中分析可能是在快速确定无反应的系统新辅助治疗的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines

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Pathway-centric analysis of the DNA damage response to chemotherapeutic agents in two breast cell lines

The response to DNA damage by alkylation and DNA topoisomerase inhibition was studied in two breast cancer cells lines. We present data from both a shotgun and a targeted, pathway-centric approach to highlight the different DNA repair pathway modulation in the cell lines and the correlation with viability and DNA damage assays. This type of focussed profiling may be of utility in rapidly defining non-responders undergoing systemic neoadjuvant therapy.

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来源期刊

EuPA Open Proteomics Biochemistry, Genetics and Molecular Biology-Biochemistry

自引率

0.00%

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审稿时长

103 days