{"title":"伊朗人群维生素D受体基因rs4334089多态性与帕金森病","authors":"Atena Fazeli , Marzieh Motallebi , Javad Jamshidi , Abolfazl Movafagh , Hamid Ghaedi , Babak Emamalizadeh , Kaveh Kashani , Hossein Darvish","doi":"10.1016/j.baga.2016.04.001","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Parkinson disease (PD) is a </span>neurodegenerative disorder<span><span> with both contributions of genetic and environmental factors. Protective functions of </span>vitamin D<span> and then vitamin D receptor (VDR) in PD have been declared recently. In this study we investigated the association of </span></span></span><em>VDR</em><span> rs4334089 gene polymorphism with PD in Iranian population.</span></p><p>A total of 1040 subjects including 520 PD patients and 520 unrelated control subjects were recruited in a case-control study. DNA was extracted from peripheral blood of all subjects and rs4334089 polymorphism of <em>VDR</em> was genotyped using PCR-RFLP method.</p><p><span>Genotype and allele frequency of rs4334089 were significantly different in PD and control groups and A allele was significantly more frequent in PD patients compared to control group. Our findings suggest that </span><em>VDR</em> rs4334089 A allele could be a risk factors for PD in Iranian population, although more replication studies are needed to confirm our findings.</p></div>","PeriodicalId":89327,"journal":{"name":"Basal ganglia","volume":"6 3","pages":"Pages 157-160"},"PeriodicalIF":0.0000,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.baga.2016.04.001","citationCount":"5","resultStr":"{\"title\":\"Vitamin D receptor gene rs4334089 polymorphism and Parkinson’s disease in Iranian population\",\"authors\":\"Atena Fazeli , Marzieh Motallebi , Javad Jamshidi , Abolfazl Movafagh , Hamid Ghaedi , Babak Emamalizadeh , Kaveh Kashani , Hossein Darvish\",\"doi\":\"10.1016/j.baga.2016.04.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Parkinson disease (PD) is a </span>neurodegenerative disorder<span><span> with both contributions of genetic and environmental factors. Protective functions of </span>vitamin D<span> and then vitamin D receptor (VDR) in PD have been declared recently. In this study we investigated the association of </span></span></span><em>VDR</em><span> rs4334089 gene polymorphism with PD in Iranian population.</span></p><p>A total of 1040 subjects including 520 PD patients and 520 unrelated control subjects were recruited in a case-control study. DNA was extracted from peripheral blood of all subjects and rs4334089 polymorphism of <em>VDR</em> was genotyped using PCR-RFLP method.</p><p><span>Genotype and allele frequency of rs4334089 were significantly different in PD and control groups and A allele was significantly more frequent in PD patients compared to control group. Our findings suggest that </span><em>VDR</em> rs4334089 A allele could be a risk factors for PD in Iranian population, although more replication studies are needed to confirm our findings.</p></div>\",\"PeriodicalId\":89327,\"journal\":{\"name\":\"Basal ganglia\",\"volume\":\"6 3\",\"pages\":\"Pages 157-160\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.baga.2016.04.001\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Basal ganglia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210533616300016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basal ganglia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210533616300016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Vitamin D receptor gene rs4334089 polymorphism and Parkinson’s disease in Iranian population
Parkinson disease (PD) is a neurodegenerative disorder with both contributions of genetic and environmental factors. Protective functions of vitamin D and then vitamin D receptor (VDR) in PD have been declared recently. In this study we investigated the association of VDR rs4334089 gene polymorphism with PD in Iranian population.
A total of 1040 subjects including 520 PD patients and 520 unrelated control subjects were recruited in a case-control study. DNA was extracted from peripheral blood of all subjects and rs4334089 polymorphism of VDR was genotyped using PCR-RFLP method.
Genotype and allele frequency of rs4334089 were significantly different in PD and control groups and A allele was significantly more frequent in PD patients compared to control group. Our findings suggest that VDR rs4334089 A allele could be a risk factors for PD in Iranian population, although more replication studies are needed to confirm our findings.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
