{"title":"搅拌生物反应器中酶活性的控制","authors":"José Alvarez, Mónica Meraz","doi":"10.1016/0300-9467(93)80010-L","DOIUrl":null,"url":null,"abstract":"<div><p>In this work the problem of determining the feed rate policy of fresh enzyme into stirred bioreactors to offset the loss of activity due to enzyme deactivation is addressed. On the basis of a series-type deactivation mechanism with arbitrary deactivation kinetics, it is shown that the feed rate policy is a feedback function of the deactivation rate. From both the theoretical and the practical viewpoints, these results provide a useful tool in understanding enzyme deactivation, and in designing bioreactor operation.</p></div>","PeriodicalId":101225,"journal":{"name":"The Chemical Engineering Journal","volume":"51 1","pages":"Pages B11-B16"},"PeriodicalIF":0.0000,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0300-9467(93)80010-L","citationCount":"3","resultStr":"{\"title\":\"Control of enzyme activity in stirred bioreactors\",\"authors\":\"José Alvarez, Mónica Meraz\",\"doi\":\"10.1016/0300-9467(93)80010-L\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this work the problem of determining the feed rate policy of fresh enzyme into stirred bioreactors to offset the loss of activity due to enzyme deactivation is addressed. On the basis of a series-type deactivation mechanism with arbitrary deactivation kinetics, it is shown that the feed rate policy is a feedback function of the deactivation rate. From both the theoretical and the practical viewpoints, these results provide a useful tool in understanding enzyme deactivation, and in designing bioreactor operation.</p></div>\",\"PeriodicalId\":101225,\"journal\":{\"name\":\"The Chemical Engineering Journal\",\"volume\":\"51 1\",\"pages\":\"Pages B11-B16\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0300-9467(93)80010-L\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Chemical Engineering Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/030094679380010L\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Chemical Engineering Journal","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/030094679380010L","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In this work the problem of determining the feed rate policy of fresh enzyme into stirred bioreactors to offset the loss of activity due to enzyme deactivation is addressed. On the basis of a series-type deactivation mechanism with arbitrary deactivation kinetics, it is shown that the feed rate policy is a feedback function of the deactivation rate. From both the theoretical and the practical viewpoints, these results provide a useful tool in understanding enzyme deactivation, and in designing bioreactor operation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
