制备2,3-二取代2,3-二氢噻唑[3,2-a]嘧啶的新方法

IF 0.8 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Doklady Chemistry Pub Date : 2023-01-30 DOI:10.1134/S0012500822700070

A. S. Agarkov, A. A. Kozhikhov, A. A. Nefedova, A. S. Ovsyannikov, D. R. Islamov, S. E. Solovieva, I. S. Antipin

引用次数: 2

摘要

研究了在微波活化条件下合成2,3-二取代2,3-二氢噻唑[3,2- A]嘧啶的新方法。该方法是在噻唑[3,2-a]嘧啶的2-芳基甲基衍生物上亲核加成甲醇，然后在分子内重排形成3,5-二烷基-2,3-二氢噻唑[3,2-a]嘧啶-2,6-二羧酸盐。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

New Method for the Preparation of 2,3-Disubstituted 2,3-Dihydrothiazolo[3,2-a]pyrimidines

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New Method for the Preparation of 2,3-Disubstituted 2,3-Dihydrothiazolo[3,2-a]pyrimidines

A new approach to the synthesis of 2,3-disubstituted 2,3-dihydrothiazolo[3,2-a]pyrimidines under microwave activation conditions has been developed. The method consists in the nucleophilic addition of methanol to 2-arylmethylidene derivatives of thiazolo[3,2-a]pyrimidine followed by intramolecular rearrangement to form 3,5-diaryl-2,3-dihydrothiazolo[3,2-a]pyrimidine-2,6-dicarboxylates.

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来源期刊

Doklady Chemistry 化学-化学综合

CiteScore

1.20

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Chemistry is a journal that publishes new research in chemistry and chemical engineering of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.