Jihed Boubaker, Zied Ghedira, Kamel Ghedira, Leila Chekir-Ghedira
{"title":"白刺叶提取物增强人慢性髓性白血病K562细胞的抗氧化活性","authors":"Jihed Boubaker, Zied Ghedira, Kamel Ghedira, Leila Chekir-Ghedira","doi":"10.1002/cbi3.10003","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <p><i>Nitraria retusa</i> leaf extracts have been investigated for their ability to induce antioxidant and antigenotoxic effects in a human chronic myelogenous leukaemia cell line. Antioxidant and antigenotoxic properties of <i>N. retusa</i> products were explored using antioxidant and the assays, respectively. Hex, Chl and MeOH extracts decreased oxidation induced by 2,2′-azobis (2-amidinopropane) dihydrochloride in human cells, with IC<sub>50</sub> concentrations of 0.6, 0.52 and 0.24 mg/mL, respectively, reflecting significant antioxidant potential. The same products inhibited the genotoxicity induced by hydroxyl radicals in the same human cell line, by 67% at 600 µg/mL, 74% at 780 µg/mL and 81.5% at 800 µg/mL, respectively.</p>\n </section>\n </div>","PeriodicalId":75683,"journal":{"name":"Cell biology international reports","volume":"20 2","pages":"5-12"},"PeriodicalIF":0.0000,"publicationDate":"2013-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/cbi3.10003","citationCount":"2","resultStr":"{\"title\":\"Antigenotoxic and antioxidant activity in human chronic myelogenous leukaemia cell line K562 enhanced by Nitraria retusa leaf extracts\",\"authors\":\"Jihed Boubaker, Zied Ghedira, Kamel Ghedira, Leila Chekir-Ghedira\",\"doi\":\"10.1002/cbi3.10003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <p><i>Nitraria retusa</i> leaf extracts have been investigated for their ability to induce antioxidant and antigenotoxic effects in a human chronic myelogenous leukaemia cell line. Antioxidant and antigenotoxic properties of <i>N. retusa</i> products were explored using antioxidant and the assays, respectively. Hex, Chl and MeOH extracts decreased oxidation induced by 2,2′-azobis (2-amidinopropane) dihydrochloride in human cells, with IC<sub>50</sub> concentrations of 0.6, 0.52 and 0.24 mg/mL, respectively, reflecting significant antioxidant potential. The same products inhibited the genotoxicity induced by hydroxyl radicals in the same human cell line, by 67% at 600 µg/mL, 74% at 780 µg/mL and 81.5% at 800 µg/mL, respectively.</p>\\n </section>\\n </div>\",\"PeriodicalId\":75683,\"journal\":{\"name\":\"Cell biology international reports\",\"volume\":\"20 2\",\"pages\":\"5-12\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/cbi3.10003\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell biology international reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cbi3.10003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell biology international reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbi3.10003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antigenotoxic and antioxidant activity in human chronic myelogenous leukaemia cell line K562 enhanced by Nitraria retusa leaf extracts
Nitraria retusa leaf extracts have been investigated for their ability to induce antioxidant and antigenotoxic effects in a human chronic myelogenous leukaemia cell line. Antioxidant and antigenotoxic properties of N. retusa products were explored using antioxidant and the assays, respectively. Hex, Chl and MeOH extracts decreased oxidation induced by 2,2′-azobis (2-amidinopropane) dihydrochloride in human cells, with IC50 concentrations of 0.6, 0.52 and 0.24 mg/mL, respectively, reflecting significant antioxidant potential. The same products inhibited the genotoxicity induced by hydroxyl radicals in the same human cell line, by 67% at 600 µg/mL, 74% at 780 µg/mL and 81.5% at 800 µg/mL, respectively.
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