天然产物是药物发现的基础

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Protocols in Pharmacology Pub Date : 2019-08-26 DOI:10.1002/cpph.67

John A. Beutler

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引用次数: 22

摘要

许多天然产物已被用作治疗各种适应症的药物。尽管多年来，大多数美国制药公司已经减少或取消了内部天然产品的研究，但化合物筛选和化学合成的新方法重新激起了人们对探索天然产品治疗价值的兴趣。这篇评论的目的是回顾新兴的战略和技术，这些战略和技术使天然产物成为药物发现计划中可行的战略选择。2019年出版。美国政府。

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Natural Products as a Foundation for Drug Discovery

Many natural products have been used as drugs for the treatment of diverse indications. Although most U.S. pharmaceutical companies have reduced or eliminated their in-house natural-product research over the years, new approaches for compound screening and chemical synthesis are resurrecting interest in exploring the therapeutic value of natural products. The aim of this commentary is to review emerging strategies and techniques that have made natural products a viable strategic choice for inclusion in drug discovery programs. Published 2019. U.S. Government.

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Current Protocols in Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

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