Zafran Khan , Daniya Ualiyeva , Khalid Jamal , Babar Ali , Fayaz Ahmad , Sanjeep Sapkota , Obed Boadi Amissah , Petuel Ndip Ndip Bate
{"title":"结核分枝杆菌的分子诊断和潜在的治疗选择：我们的立场","authors":"Zafran Khan , Daniya Ualiyeva , Khalid Jamal , Babar Ali , Fayaz Ahmad , Sanjeep Sapkota , Obed Boadi Amissah , Petuel Ndip Ndip Bate","doi":"10.1016/j.meomic.2023.100022","DOIUrl":null,"url":null,"abstract":"<div><p><em>Mycobacterium tuberculosis<!--> </em>(Mtb) is a causative agent of the infectious disease tuberculosis (TB), which has hampered susceptible populations in modern-day societies for years. Additionally, the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR)<!--> <!-->Mtb<!--> <!-->strains has intensified this global health issue. Each year the global death tally spikes by 1.6 million, and additional 10.6 million new cases of TB. Researchers are trying to find a treatment, mainly emphasizing the anti-tubercular drugs and/or vaccines that could potentially control the spread of TB to manage the associated health issue. To date, more than 20 anti-tubercular drugs have been developed and used at various stages of TB. The current review aims to discuss/describe useful information about available TB treatments and anti-tubercular resistance. Moreover, we also highlighted diagnostic approaches and current drug reserves for drug-resistant TB (DR-TB).</p></div>","PeriodicalId":100914,"journal":{"name":"Medicine in Omics","volume":"8 ","pages":"Article 100022"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Molecular diagnostics and potential therapeutic options for mycobacterium tuberculosis: Where we stand\",\"authors\":\"Zafran Khan , Daniya Ualiyeva , Khalid Jamal , Babar Ali , Fayaz Ahmad , Sanjeep Sapkota , Obed Boadi Amissah , Petuel Ndip Ndip Bate\",\"doi\":\"10.1016/j.meomic.2023.100022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>Mycobacterium tuberculosis<!--> </em>(Mtb) is a causative agent of the infectious disease tuberculosis (TB), which has hampered susceptible populations in modern-day societies for years. Additionally, the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR)<!--> <!-->Mtb<!--> <!-->strains has intensified this global health issue. Each year the global death tally spikes by 1.6 million, and additional 10.6 million new cases of TB. Researchers are trying to find a treatment, mainly emphasizing the anti-tubercular drugs and/or vaccines that could potentially control the spread of TB to manage the associated health issue. To date, more than 20 anti-tubercular drugs have been developed and used at various stages of TB. The current review aims to discuss/describe useful information about available TB treatments and anti-tubercular resistance. Moreover, we also highlighted diagnostic approaches and current drug reserves for drug-resistant TB (DR-TB).</p></div>\",\"PeriodicalId\":100914,\"journal\":{\"name\":\"Medicine in Omics\",\"volume\":\"8 \",\"pages\":\"Article 100022\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicine in Omics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590124923000032\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine in Omics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590124923000032","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Molecular diagnostics and potential therapeutic options for mycobacterium tuberculosis: Where we stand
Mycobacterium tuberculosis (Mtb) is a causative agent of the infectious disease tuberculosis (TB), which has hampered susceptible populations in modern-day societies for years. Additionally, the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb strains has intensified this global health issue. Each year the global death tally spikes by 1.6 million, and additional 10.6 million new cases of TB. Researchers are trying to find a treatment, mainly emphasizing the anti-tubercular drugs and/or vaccines that could potentially control the spread of TB to manage the associated health issue. To date, more than 20 anti-tubercular drugs have been developed and used at various stages of TB. The current review aims to discuss/describe useful information about available TB treatments and anti-tubercular resistance. Moreover, we also highlighted diagnostic approaches and current drug reserves for drug-resistant TB (DR-TB).
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