癫痫精神病:伊朗10年临床调查。

Q2 Medicine
Mahan Shafie, Jaber Darijani, Zahra Mirsepassi, Alireza Razavi, Mahsa Mayeli, Mohammad Arbabi, Vajiheh Aghamollaii
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引用次数: 0

摘要

目的:癫痫精神病通常起病急性,症状持续时间短,有复发的风险。由于某些抗精神病药物可能会导致癫痫发作,以及一些抗癫痫药物会加剧精神病,因此管理这些情况可能具有挑战性。本研究的目的是评估癫痫患者中精神病的发生率,并确定与该人群中精神病存在和严重程度相关的因素。方法:在这项研究中,我们纳入了2011年4月至2021年12月在德黑兰医学科学大学附属神经精神科诊所诊断为癫痫的514名受试者,其中57名患者表现为精神病。我们比较了癫痫精神病患者和同时患有癫痫的非精神病患者的基线和临床特征。结果:婚姻状况是唯一一个在精神病组和非精神病组之间显示出统计学显著差异的人口统计学因素(P=0.019)。在癫痫家族史和癫痫发作时的年龄方面,两组之间没有观察到显著差异。精神病患者的癫痫发作频率和一般型明显高于对照组(P<0.001),除精神病频率外(P=0.007)。调整协变量后,癫痫类型与精神病显著相关(P<0.001)。结论:癫痫精神病患者比非精神病患者经历了更多的癫痫发作。我们确定全身性癫痫是发展为精神病的独立危险因素。需要更多的队列来探索不同人群中与癫痫相关的精神病相关的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey.

Objective: Psychoses of epilepsy usually have an acute onset, accompanied by brief symptom duration and a risk of recurrence. Managing these conditions can be challenging due to the potential for seizures associated with certain antipsychotic medications, as well as exacerbating psychosis resulting from some antiepileptic medications. Our objective in this study was to assess the occurrence of psychosis among patients with epilepsy, as well as identify the factors linked to the presence and severity of psychosis in this population. Method : In this study, we included a total of 514 subjects diagnosed with epilepsy referring to our neuropsychiatry clinic affiliated with Tehran University of Medical Sciences from April 2011 to December 2021, among whom 57 patients showed psychotic presentations. We compared baseline and clinical characteristics between patients with psychosis of epilepsy and non-psychosis patients who also had epilepsy. Results: Marital status was the sole demographic factor that displayed a statistically significant difference between the psychosis and non-psychosis groups (P = 0.019). There was no significant difference observed between the two groups regarding family history of epilepsy and age at the onset of the epilepsy. Patients with psychosis experienced significantly more frequent seizures and generalized type (P < 0.001). Participants were matched for demographics and other clinical factors between the refractory and controlled psychosis groups, except for the psychosis frequency (P = 0.007). The type of epilepsy was significantly associated with psychosis when adjusted for the covariates (P < 0.001). Conclusion: Patients with psychosis of epilepsy experienced more episodes of epilepsy than non-psychotics. We identified generalized epilepsy as an independent risk factor for the development of psychosis. Additional cohorts are warranted to explore the factors associated with epilepsy-related psychosis across diverse populations.

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来源期刊
Iranian Journal of Psychiatry
Iranian Journal of Psychiatry Medicine-Psychiatry and Mental Health
CiteScore
4.00
自引率
0.00%
发文量
42
审稿时长
4 weeks
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