{"title":"IGF-1被证明是预测1型糖尿病的潜在新生物标志物","authors":"","doi":"10.1002/doi2.00004","DOIUrl":null,"url":null,"abstract":"<p>A recent study published in Nature investigated total serum IGF1, IGF2, and IGFBP1–7 levels were measured in an age-matched, cross-sectional cohort at varying stages of progression to type 1 diabetes showed that the levels and biovailability of Insulin-like growth factors (IGFs), are reduced during type 1 diabetes development. In the study. Further, IGF1 levels decreased over time in subjects with multiple auto Antibodies and those who progressed to type 1 diabetes, particularly post-diagnosis. This study therefore showed IGFs are dysregulated both before and after the clinical diagnosis of type 1 diabetes and may be used as novel biomarkers predict type 1 diabetes in the future.</p><p>URL: https://www.nature.com/articles/s41574-020-0317-0</p>","PeriodicalId":100370,"journal":{"name":"Diabetes, Obesity and Metabolism Now","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/doi2.00004","citationCount":"0","resultStr":"{\"title\":\"IGF-1 shown to be a potential novel biomarker to predict type 1 diabetes\",\"authors\":\"\",\"doi\":\"10.1002/doi2.00004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A recent study published in Nature investigated total serum IGF1, IGF2, and IGFBP1–7 levels were measured in an age-matched, cross-sectional cohort at varying stages of progression to type 1 diabetes showed that the levels and biovailability of Insulin-like growth factors (IGFs), are reduced during type 1 diabetes development. In the study. Further, IGF1 levels decreased over time in subjects with multiple auto Antibodies and those who progressed to type 1 diabetes, particularly post-diagnosis. This study therefore showed IGFs are dysregulated both before and after the clinical diagnosis of type 1 diabetes and may be used as novel biomarkers predict type 1 diabetes in the future.</p><p>URL: https://www.nature.com/articles/s41574-020-0317-0</p>\",\"PeriodicalId\":100370,\"journal\":{\"name\":\"Diabetes, Obesity and Metabolism Now\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-04-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/doi2.00004\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes, Obesity and Metabolism Now\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/doi2.00004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes, Obesity and Metabolism Now","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/doi2.00004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
IGF-1 shown to be a potential novel biomarker to predict type 1 diabetes
A recent study published in Nature investigated total serum IGF1, IGF2, and IGFBP1–7 levels were measured in an age-matched, cross-sectional cohort at varying stages of progression to type 1 diabetes showed that the levels and biovailability of Insulin-like growth factors (IGFs), are reduced during type 1 diabetes development. In the study. Further, IGF1 levels decreased over time in subjects with multiple auto Antibodies and those who progressed to type 1 diabetes, particularly post-diagnosis. This study therefore showed IGFs are dysregulated both before and after the clinical diagnosis of type 1 diabetes and may be used as novel biomarkers predict type 1 diabetes in the future.
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