Gly-m4-特异性IgE检测对桦树科花粉致敏引起的蔷薇科果实口腔过敏综合征的诊断价值

IF 1.1 Q4 ALLERGY
Tokiko Yoshida MD, Eishin Morita PhD, Yuko Chinuki PhD, Kunie Kohno PhD, Osamu Yamasaki PhD
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引用次数: 0

摘要

背景花粉食物过敏综合征(PFAS)是由特定IgE对花粉过敏原与水果、蔬菜和坚果中类似过敏原的交叉反应引起的。引起这种交叉反应的代表性过敏原是发病机制相关蛋白(PR)-10。大豆PR-10的特异性IgE检测广泛应用于大豆过敏的诊断。我们的目的是研究Gly m-4特异性IgE测试是否有助于预测桦木科花粉致敏引起的PFAS对蔷薇科水果的口腔过敏症状。方法选择41例疑似PFAS患者。对赤杨花粉、苹果、桃、梨和Gly m4的特异性IgE水平进行了测量,并评估了测试结果与过敏症状之间的相关性,以比较这些过敏原特异性IgE测试的准确性。结果41例患者中,32例为赤杨花粉特异性IgE阳性。其中,16例对苹果、桃和梨中的至少一种表现出OAS(OAS(+)组),其余16例无症状(OAS)组)。OAS(+)组的Gly m 4-特异性IgE值显著较高(p=0.014),在受试者操作特征曲线下的区域最高。OAS(+)组的检测截止值为2.65 UA/ml,敏感性为62.5%,特异性为81.3%。其他过敏原特异性IgE值在两组之间没有显著差异。结论在对桦木科花粉过敏原敏感的人群中,Gly-m4-特异性IgE试验可用于预测蔷薇科果实的OAS。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Usefulness of Gly m 4-specific IgE test in the diagnosis of Rosaceae fruit-oral allergy syndrome caused by Betulaceae pollen sensitization

Usefulness of Gly m 4-specific IgE test in the diagnosis of Rosaceae fruit-oral allergy syndrome caused by Betulaceae pollen sensitization

Background

Pollen-food allergy syndrome (PFAS) is caused by the cross-reaction of the specific IgE to pollen allergens with similar allergens contained in fruits, vegetable, and nuts. The representative allergen responsible for this cross-reaction is pathogenesis-related protein (PR)-10. Specific IgE test using Gly m 4, soybean PR-10, is widely used to diagnose soy allergy. We aimed to investigate whether the Gly m 4-specific IgE test is useful for predicting oral allergy symptoms (OAS) to Rosaceae fruits in PFAS caused by Betulaceae pollen sensitization.

Methods

Forty-one patients with suspected PFAS were enrolled. Specific IgE levels were measured against alder pollen, apple, peach, pear, and Gly m 4, and correlation between test results and allergic symptoms was assessed to compare the accuracy of these allergen-specific IgE tests.

Results

Of the 41 patients, 32 were positive for alder pollen-specific IgE. Of those, 16 showed OAS to at least one of apple, peach, and pear (OAS (+) group), and the rest 16 cases showed no symptoms (OAS (−) group). The Gly m 4-specific IgE value was significantly higher in the OAS (+) group (p = .014), and the highest in area under the receiver operating characteristics curve. The cut-off value for detection of the OAS (+) group was 2.65 UA/ml, with a sensitivity of 62.5% and a specificity of 81.3%. Other allergen-specific IgE values were not significantly different between the two groups.

Conclusions

In the subjects sensitized to Betulaceae pollen allergens, the Gly m 4-specific IgE test is useful for predicting OAS of Rosaceae fruits.

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来源期刊
CiteScore
0.60
自引率
10.00%
发文量
69
审稿时长
12 weeks
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