使用字符串压缩高效构建重复文本的BWT

IF 0.8 4区 计算机科学 Q3 COMPUTER SCIENCE, THEORY & METHODS
Diego Díaz-Domínguez , Gonzalo Navarro
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引用次数: 0

摘要

我们提出了一种新的半外部算法,该算法在线性预期时间内构建Bauer等人的Burrows–Wheeler变换变体(又名BCR-BWT)。当输入量巨大且重复时,我们的方法使用压缩技术来降低计算成本。具体来说,我们建立在诱导后缀排序(ISS)的基础上,并采用行程长度和语法压缩来保持中间结果的紧凑形式。我们的压缩格式不仅节省了空间,而且加快了所需的计算。我们的实验表明,当文本重复时,可以节省大量的空间和计算时间。在中等规模的真实人类基因组集合(14.2 GB-75.05 GB)中,我们的记忆峰值平均比最先进的BCR BWT构建算法(ropebwt2)的峰值小1.7倍,同时运行速度快5倍。我们目前的实现还能够使用118.83 GB的工作内存(约为输入大小的10%)在41.21小时内计算出400个真实人类基因组组件(1.2 TB)的BCR BWT。有趣的是,我们在1.2 TB文件中报告的结果主要是在内存限制(特别是I/O操作)下扫描巨大文件的困难。这一事实表明,通过更仔细地实现我们的方法,我们可以执行得更好,从而有效地扩展到更大的规模。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficient construction of the BWT for repetitive text using string compression

We present a new semi-external algorithm that builds the Burrows–Wheeler transform variant of Bauer et al. (a.k.a., BCR BWT) in linear expected time. Our method uses compression techniques to reduce computational costs when the input is massive and repetitive. Concretely, we build on induced suffix sorting (ISS) and resort to run-length and grammar compression to maintain our intermediate results in compact form. Our compression format not only saves space but also speeds up the required computations. Our experiments show important space and computation time savings when the text is repetitive. In moderate-size collections of real human genome assemblies (14.2 GB - 75.05 GB), our memory peak is, on average, 1.7x smaller than the peak of the state-of-the-art BCR BWT construction algorithm (ropebwt2), while running 5x faster. Our current implementation was also able to compute the BCR BWT of 400 real human genome assemblies (1.2 TB) in 41.21 hours using 118.83 GB of working memory (around 10% of the input size). Interestingly, the results we report in the 1.2 TB file are dominated by the difficulties of scanning huge files under memory constraints (specifically, I/O operations). This fact indicates we can perform much better with a more careful implementation of our method, thus scaling to even bigger sizes efficiently.

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来源期刊
Information and Computation
Information and Computation 工程技术-计算机:理论方法
CiteScore
2.30
自引率
0.00%
发文量
119
审稿时长
140 days
期刊介绍: Information and Computation welcomes original papers in all areas of theoretical computer science and computational applications of information theory. Survey articles of exceptional quality will also be considered. Particularly welcome are papers contributing new results in active theoretical areas such as -Biological computation and computational biology- Computational complexity- Computer theorem-proving- Concurrency and distributed process theory- Cryptographic theory- Data base theory- Decision problems in logic- Design and analysis of algorithms- Discrete optimization and mathematical programming- Inductive inference and learning theory- Logic & constraint programming- Program verification & model checking- Probabilistic & Quantum computation- Semantics of programming languages- Symbolic computation, lambda calculus, and rewriting systems- Types and typechecking
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