肉仔鸡肝脏热应激反应的CUT&tag-seq分析为日粮根皮素提高耐热性提供了新的见解

IF 3.5 2区 农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY
Hong Hu , Liang Chen , Ying Huang , Kunping Wang , Xi Bai , Hongbin Pan
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引用次数: 1

摘要

本工作旨在通过靶下切割和标记结合高通量测序(CUT&;Tag-seq),研究根皮素通过核因子-红系2相关2(Nrf2)-DNA相互作用对热应激肉鸡肝脏抗氧化特性的影响。将160只22日龄Arbor Acres肉鸡分为4组:常温组(NT:22.8–23.4°C,湿度46–55.8%)饲喂基础日粮,100mg/kg(LT组)和200mg/kg(PT组)根皮素。取42日龄肉鸡的肝脏样品。高温条件下丙二醛(MDA)水平升高(P≤0.05),谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和Nrf2的活性和mRNA表达水平降低(P≤0.05。日粮200 mg/kg根皮素可降低(P≤0.05)热应激肉鸡肝脏MDA水平,但可提高(P≤0.01)GSH-Px、SOD、CAT和Nrf2的活性和mRNA表达水平。CUT&;Tag-seq显示,与HT组相比,PT组有4042个DEP上调,而2322个DEPs下调。DEPs的Nrf2结合基因包含SOD3、CAT、SOD2和p38丝裂原活化蛋白激酶。大多数TOP20重要的KEGG途径与“环境信息处理”有关。总之,根皮素可以改善热应激肉鸡肝脏中Nrf2及其下游DNA位点(包括基因和Nrf2结合的非编码RNA)的氧化损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CUT&tag-seq analysis of heat stress response in broiler liver provides novel insights into the improved thermotolerance by dietary phloretin
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来源期刊
Annals of Agricultural Science
Annals of Agricultural Science AGRICULTURE, MULTIDISCIPLINARY-
CiteScore
12.60
自引率
0.00%
发文量
18
审稿时长
33 days
期刊介绍: Annals of Agricultural Sciences (AOAS) is the official journal of Faculty of Agriculture, Ain Shams University. AOAS is an open access peer-reviewed journal publishing original research articles and review articles on experimental and modelling research at laboratory, field, farm, landscape, and industrial levels. AOAS aims to maximize the quality of the agricultural sector across the globe with emphasis on the Arabian countries by focusing on publishing the high-quality applicable researches, in addition to the new methods and frontiers leading to maximizing the quality and quantity of both plant and animal yield and final products.
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