循环微rna与易感和新诊断的2型糖尿病病例的关系

Syed Tasleem Raza , Saliha Rizvi , Sheeba Afreen , Sanchita Srivastava , Zainab Siddiqui , Naseem Fatima , Zeba Siddiqi , Farzana Mahdi
{"title":"循环微rna与易感和新诊断的2型糖尿病病例的关系","authors":"Syed Tasleem Raza , Saliha Rizvi , Sheeba Afreen , Sanchita Srivastava , Zainab Siddiqui , Naseem Fatima , Zeba Siddiqi , Farzana Mahdi","doi":"10.1016/j.abst.2023.05.001","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":72080,"journal":{"name":"Advances in biomarker sciences and technology","volume":"5 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases\",\"authors\":\"Syed Tasleem Raza , Saliha Rizvi , Sheeba Afreen , Sanchita Srivastava , Zainab Siddiqui , Naseem Fatima , Zeba Siddiqi , Farzana Mahdi\",\"doi\":\"10.1016/j.abst.2023.05.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":72080,\"journal\":{\"name\":\"Advances in biomarker sciences and technology\",\"volume\":\"5 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in biomarker sciences and technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2543106423000054\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in biomarker sciences and technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2543106423000054","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

背景糖尿病(DM)是一系列代谢性疾病,其原因是胰岛素分泌失调或其作用导致血糖水平异常高,与长期损伤、器官衰竭有关,尤其是眼睛、心脏、肾脏、血管和神经,其频率在全球范围内逐渐增加。目的本研究旨在评估新诊断的T2DM易感个体和健康对照个体的血浆miRNA-126、miRNA-486、miRNA-223和miRNA-375水平。方法在本研究中,我们使用实时聚合酶链式反应(RT-PCR)(Taqman®)评估了三个研究组(包括健康对照组(N=36)、新诊断的T2DM(N=29)和T2DM易感个体(N=30))血浆中与T2DM相关的miRNA-miRNA-126、miRNA-486、miRNA-223和miRNA-375。所有统计分析均采用SPSS 21版软件进行。结果发现这些参数之间存在显著相关性。与健康对照组相比,miR-126、miR-486、miR-223和miR-375的表达水平在T2DM患者中下调,在T2DM易感个体中进一步降低。此外,在组合组分析中,miR-223和miR-375与HbA1c水平呈负相关,而所有四种miR均与FBS水平呈负相关性。结论这些观察到的关联进一步表明,miR-126、miR-223和miR-375可能参与葡萄糖代谢和血糖控制的调节。它们的下调可能导致胰岛素信号受损、β细胞功能障碍、炎症和葡萄糖稳态紊乱,所有这些都是糖尿病的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Advances in biomarker sciences and technology
Advances in biomarker sciences and technology Biotechnology, Clinical Biochemistry, Molecular Medicine, Public Health and Health Policy
自引率
0.00%
发文量
0
审稿时长
20 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信