Carlos Roncero Parra , Alfonso Parreño Torres , Jorge Mateo Sotos , Alejandro L. Borja
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Classification of Moderate and Advanced Alzheimer's Patients Using Radial Basis Function Based Neural Networks Initialized with Fuzzy Logic
Background
Alzheimer's disease can be diagnosed through various clinical methods. Among them, electroencephalography has proven to be a powerful, non-invasive, affordable, and painless tool for its diagnosis.
Objectives
In this study, eight machine learning (ML) approaches, including SVM, BLDA, DT, GNB, KNN, RF, and deep learning (DL) methods such as RNN and RBF, were employed to classify Alzheimer's disease into two stages: moderate Alzheimer's disease (ADM) and advanced Alzheimer's disease (ADA).
Material and methods
To this aim, electroencephalography data collected from five different hospitals over a decade has been used. A novel method based on neural networks has been proposed to increase accuracy and obtain fast classification times.
Results
Results show that deep neuronal networks based on radial basis functions initialized with fuzzy means achieved the best balanced accuracy with 96.66% accuracy in ADA classification and 93.31% accuracy in ADM classification.
Conclusion
Apart from improving accuracy, it is noteworthy that this algorithm had never been used before to classify patients with Alzheimer's disease.
期刊介绍:
IRBM is the journal of the AGBM (Alliance for engineering in Biology an Medicine / Alliance pour le génie biologique et médical) and the SFGBM (BioMedical Engineering French Society / Société française de génie biologique médical) and the AFIB (French Association of Biomedical Engineers / Association française des ingénieurs biomédicaux).
As a vehicle of information and knowledge in the field of biomedical technologies, IRBM is devoted to fundamental as well as clinical research. Biomedical engineering and use of new technologies are the cornerstones of IRBM, providing authors and users with the latest information. Its six issues per year propose reviews (state-of-the-art and current knowledge), original articles directed at fundamental research and articles focusing on biomedical engineering. All articles are submitted to peer reviewers acting as guarantors for IRBM''s scientific and medical content. The field covered by IRBM includes all the discipline of Biomedical engineering. Thereby, the type of papers published include those that cover the technological and methodological development in:
-Physiological and Biological Signal processing (EEG, MEG, ECG…)-
Medical Image processing-
Biomechanics-
Biomaterials-
Medical Physics-
Biophysics-
Physiological and Biological Sensors-
Information technologies in healthcare-
Disability research-
Computational physiology-
…