子宫内膜异位症患者免疫微环境的意义。

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Ioana Păvăleanu, Raluca Anca Balan, Adriana Grigoraş, Teodora Ana Balan, Cornelia Amălinei
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引用次数: 0

摘要

子宫内膜异位症是一种女性生殖系统和腹膜内外区域的雌激素依赖性疾病,具有慢性特征。目前,免疫细胞,如巨噬细胞和淋巴细胞,被认为通过基质重塑在血管生成和子宫内膜异位细胞侵袭中发挥着关键作用。此外,各种研究揭示了E-钙粘蛋白、β-连环蛋白以及类固醇激素受体在子宫内膜异位症发展中的作用。在此背景下,我们的研究旨在分析细胞免疫谱与子宫内膜异位症组织中E-钙粘蛋白、β-连环蛋白、雌激素受体α(ERα)和孕激素受体(PR)免疫表达之间的关系,并分析血清学参数与免疫组化(IHC)标记物之间的可能关联。该研究包括53名被诊断为卵巢或皮肤腹壁子宫内膜异位症的患者,这些患者已通过常规组织学、免疫组织化学和血清分析进行了研究。IHC检查显示分化簇(CD)4+T细胞、CD8+T细胞和CD68+巨噬细胞的密度增加,同时E-钙粘蛋白、β-连环蛋白、ERα和PR的表达可变增加
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The significance of immune microenvironment in patients with endometriosis.

Endometriosis represents an estrogen-dependent disease of the female reproductive system and intra- and extraperitoneal regions, with chronic feature. Currently, immune cells, such as macrophages and lymphocytes, are considered to play a pivotal role in angiogenesis and invasion of endometriotic cells through matrix remodeling. Additionally, various studies have revealed the role of E-cadherin, β-catenin, along with steroid hormone receptors in endometriosis development. In this context, our study aimed to analyze the relationship between the cellular immune profile and E-cadherin, β-catenin, estrogen receptor alpha (ERα), and progesterone receptor (PR) immunoexpression in endometriosis tissues, along with an analysis of the possible association between serological parameters and immunohistochemical (IHC) markers. The study included 53 patients diagnosed with ovarian or cutaneous abdominal wall endometriosis, which have been investigated by routine histology, immunohistochemistry, and serum analysis. The IHC exam showed an increased density of cluster of differentiation (CD)4+ T-cells, CD8+ T-cells, and CD68+ macrophages, along with variable increased expressions of E-cadherin, β-catenin, ERα, and PR. Statistical analysis revealed an intense positive correlation between CD68 and PR expression (p<0.05), without any other statistically significant correlations between IHC markers or between IHC and serological markers. Our study supports that endometriosis is an immune-dependent disease characterized by an abnormal morphological profile of T-cells and macrophages in endometriotic implants. Our study provides additional data useful in the understanding the immune milieu of endometriosis in the context of its complex pathogenic molecular mechanism. Further research is needed to develop new immunological therapeutic approaches, like immune checkpoint inhibitors administration or T-cell-targeted immunotherapy in these patients.

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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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