星形胶质细胞——神经退行性疾病的朋友或敌人。

IF 1.2 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Romanian Journal of Morphology and Embryology Pub Date : 2023-07-01 DOI:10.47162/RJME.64.3.02

Alexandra Diana Vrapciu, Mugurel Constantin Rusu, Adelina Maria Jianu, Andrei Gheorghe Marius Motoc, Mihnea Ioan Nicolescu

{"title":"星形胶质细胞——神经退行性疾病的朋友或敌人。","authors":"Alexandra Diana Vrapciu, Mugurel Constantin Rusu, Adelina Maria Jianu, Andrei Gheorghe Marius Motoc, Mihnea Ioan Nicolescu","doi":"10.47162/RJME.64.3.02","DOIUrl":null,"url":null,"abstract":"Astrocytes (AS) are the most abundant glial cells in the central nervous system (CNS). They have various morphologies and numerous (50-60) branching prolongations, with roles in the maintenance of the CNS function and homeostasis. AS in the optic nerve head (ONH) have specific distribution and function and are involved in the pathogenesis of glaucoma and other neural diseases, modify their morphologies, location, immune phenotype, and ultrastructure, thus being the key players in the active remodeling processes of the ONH.","PeriodicalId":54447,"journal":{"name":"Romanian Journal of Morphology and Embryology","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10720932/pdf/","citationCount":"0","resultStr":"{\"title\":\"Astrocytes - friends or foes in neurodegenerative disorders.\",\"authors\":\"Alexandra Diana Vrapciu, Mugurel Constantin Rusu, Adelina Maria Jianu, Andrei Gheorghe Marius Motoc, Mihnea Ioan Nicolescu\",\"doi\":\"10.47162/RJME.64.3.02\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Astrocytes (AS) are the most abundant glial cells in the central nervous system (CNS). They have various morphologies and numerous (50-60) branching prolongations, with roles in the maintenance of the CNS function and homeostasis. AS in the optic nerve head (ONH) have specific distribution and function and are involved in the pathogenesis of glaucoma and other neural diseases, modify their morphologies, location, immune phenotype, and ultrastructure, thus being the key players in the active remodeling processes of the ONH.\",\"PeriodicalId\":54447,\"journal\":{\"name\":\"Romanian Journal of Morphology and Embryology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10720932/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian Journal of Morphology and Embryology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.47162/RJME.64.3.02\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DEVELOPMENTAL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Journal of Morphology and Embryology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47162/RJME.64.3.02","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

星形胶质细胞（AS）是中枢神经系统（CNS）中最丰富的胶质细胞。它们具有各种形态和许多（50-60）分支延长，在维持中枢神经系统功能和稳态中发挥作用。视神经头（ONH）中的AS具有特定的分布和功能，参与青光眼和其他神经疾病的发病机制，改变其形态、位置、免疫表型和超微结构，因此是ONH主动重塑过程中的关键参与者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Astrocytes - friends or foes in neurodegenerative disorders.

Astrocytes (AS) are the most abundant glial cells in the central nervous system (CNS). They have various morphologies and numerous (50-60) branching prolongations, with roles in the maintenance of the CNS function and homeostasis. AS in the optic nerve head (ONH) have specific distribution and function and are involved in the pathogenesis of glaucoma and other neural diseases, modify their morphologies, location, immune phenotype, and ultrastructure, thus being the key players in the active remodeling processes of the ONH.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Romanian Journal of Morphology and Embryology DEVELOPMENTAL BIOLOGY-

CiteScore

1.70

自引率

20.00%

发文量

221

审稿时长

3-8 weeks

期刊介绍： Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).