非泡状神经酰胺转运机制。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2023-10-17 eCollection Date: 2023-01-01 DOI:10.1177/25152564231208250
Lena Clausmeyer, Florian Fröhlich
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引用次数: 0

摘要

神经酰胺作为细胞膜的关键成分,在各种细胞过程中发挥着重要作用,包括细胞凋亡、细胞增殖和细胞信号传导。神经酰胺是真核细胞中所有复杂鞘脂的前体。它们在内质网中合成,并在高尔基体中进一步加工。因此,神经酰胺必须在这两个细胞器之间进行转运。在哺乳动物细胞中,神经酰胺转移蛋白在ER和反式高尔基体区域之间形成接触位点,并利用其类固醇生成急性调节蛋白相关的脂质转移结构域转运神经酰胺。在酵母中,已经描述了非球形神经酰胺转运的多种机制。这涉及核液泡连接蛋白Nvj2、酵母三钙蛋白和脂质运载蛋白样蛋白Svf1。这篇综述的目的是提供一个全面的综述非泡神经酰胺转运机制及其在细胞生理学中的相关性。我们将强调非泡状神经酰胺转运中扰动的生理和病理后果,并讨论鉴定和分析神经酰胺转移蛋白的未来挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mechanisms of Nonvesicular Ceramide Transport.

Mechanisms of Nonvesicular Ceramide Transport.

Mechanisms of Nonvesicular Ceramide Transport.

Mechanisms of Nonvesicular Ceramide Transport.

Ceramides, as key components of cellular membranes, play essential roles in various cellular processes, including apoptosis, cell proliferation, and cell signaling. Ceramides are the precursors of all complex sphingolipids in eukaryotic cells. They are synthesized in the endoplasmic reticulum and are further processed at the Golgi apparatus. Therefore, ceramides have to be transported between these two organelles. In mammalian cells, the ceramide transfer protein forms a contact site between the ER and the trans-Golgi region and transports ceramide utilizing its steroidogenic acute regulatory protein-related lipid transfer domain. In yeast, multiple mechanisms of nonvesicular ceramide transport have been described. This involves the nuclear-vacuolar junction protein Nvj2, the yeast tricalbin proteins, and the lipocalin-like protein Svf1. This review aims to provide a comprehensive overview of nonvesicular ceramide transport mechanisms and their relevance in cellular physiology. We will highlight the physiological and pathological consequences of perturbations in nonvesicular ceramide transport and discuss future challenges in identifying and analyzing ceramide transfer proteins.

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