创伤性肌肉损伤。

IF 76.9 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Pascal Edouard, Gustaaf Reurink, Abigail L Mackey, Richard L Lieber, Tania Pizzari, Tero A H Järvinen, Thomas Gronwald, Karsten Hollander
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引用次数: 0

摘要

创伤性肌肉损伤代表由肌肉组织创伤引起的骨骼肌病理的集合,并被定义为可能导致功能缺陷的肌肉组织损伤。创伤性肌肉损伤会影响人的一生,可能是由于骨骼肌组织的高应力和应变,通常是由于肌肉延长时的肌肉激活,导致间接和非接触性肌肉损伤(应变或破裂),也可能是由于外部冲击,导致直接肌肉损伤(挫伤或撕裂伤)。在显微镜下,肌肉纤维可以修复局灶性损伤,但必须在肌纤维完全坏死后完全再生。肌肉损伤的诊断是基于患者病史和身体检查。可以指示成像以消除鉴别诊断。在过去的5年里,肌肉损伤的管理已经发生了变化,从最初的休息、固定和(过度)保护到早期激活和使用主动方法的渐进负荷。肌肉损伤管理的一个挑战是,尽管疗效证据非常有限,但仍经常使用或提出多种药物治疗方案,如药物和注射,以加速肌肉恢复。另一个挑战是预防肌肉损伤,因为这种损伤具有多因素和复杂性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Traumatic muscle injury.

Traumatic muscle injury.

Traumatic muscle injury represents a collection of skeletal muscle pathologies caused by trauma to the muscle tissue and is defined as damage to the muscle tissue that can result in a functional deficit. Traumatic muscle injury can affect people across the lifespan and can result from high stresses and strains to skeletal muscle tissue, often due to muscle activation while the muscle is lengthening, resulting in indirect and non-contact muscle injuries (strains or ruptures), or from external impact, resulting in direct muscle injuries (contusion or laceration). At a microscopic level, muscle fibres can repair focal damage but must be completely regenerated after full myofibre necrosis. The diagnosis of muscle injury is based on patient history and physical examination. Imaging may be indicated to eliminate differential diagnoses. The management of muscle injury has changed within the past 5 years from initial rest, immobilization and (over)protection to early activation and progressive loading using an active approach. One challenge of muscle injury management is that numerous medical treatment options, such as medications and injections, are often used or proposed to try to accelerate muscle recovery despite very limited efficacy evidence. Another challenge is the prevention of muscle injury owing to the multifactorial and complex nature of this injury.

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来源期刊
Nature Reviews Disease Primers
Nature Reviews Disease Primers Medicine-General Medicine
CiteScore
76.70
自引率
0.20%
发文量
75
期刊介绍: Nature Reviews Disease Primers, a part of the Nature Reviews journal portfolio, features sections on epidemiology, mechanisms, diagnosis, management, and patient quality of life. The editorial team commissions top researchers — comprising basic scientists and clinical researchers — to write the Primers, which are designed for use by early career researchers, medical students and principal investigators. Each Primer concludes with an Outlook section, highlighting future research directions. Covered medical specialties include Cardiology, Dermatology, Ear, Nose and Throat, Emergency Medicine, Endocrinology, Gastroenterology, Genetic Conditions, Gynaecology and Obstetrics, Hepatology, Haematology, Infectious Diseases, Maxillofacial and Oral Medicine, Nephrology, Neurology, Nutrition, Oncology, Ophthalmology, Orthopaedics, Psychiatry, Respiratory Medicine, Rheumatology, Sleep Medicine, and Urology.
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