为患有大麻使用障碍和精神病的住院青少年选择阿立哌唑或利培酮的方案评估。

IF 1.5 4区 医学 Q2 PEDIATRICS
Christian Thurstone, Ryan Loh, Kristina Foreman, Christian A Thurstone, Chelsea Wolf
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引用次数: 0

摘要

引言:同时使用大麻和精神病是一个日益严重的问题。没有一种单一的行为或药物治疗方法表现出明显的优越性。为了弥补这一差距,这个非随机的质量改进项目比较了同时患有大麻使用障碍和精神病的青少年服用利培酮或阿立哌唑的结果。材料和方法:该项目对110名因精神病和并发大麻使用障碍住院的青少年(年龄13-21岁)进行了回顾性图表审查。主要结果是住院时间和住院时间指数。结果:与阿立哌唑相比,服用利培酮的青少年的住院时间明显更长(9.7天vs.5.8天,p = 0.002)和停留时间指数(1.4对0.79,p = 0.004)。结论:因合并精神病和大麻使用障碍住院的青少年的住院时间和住院时间指数明显更长。这些数据与阿立哌唑与利培酮相比,在同时发生的大麻使用障碍的情况下,急性精神病症状更快地减轻是一致的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Program Evaluation to Aid Choice of Aripiprazole or Risperidone for Hospitalized Adolescents with Cannabis Use Disorder and Psychosis.

Introduction: Co-occurring cannabis use and psychosis is an increasing problem. No single behavioral or pharmacologic treatment has emerged as clearly superior. To address the gap, this nonrandomized, quality improvement project compares outcomes for adolescents with co-occurring cannabis use disorder and psychosis prescribed risperidone or aripiprazole. Materials and Methods: This project is a retrospective chart review of 110 adolescents (ages 13-21 years) hospitalized for psychosis and co-occurring cannabis use disorder. The primary outcomes are length of stay and length of stay index. Results: Adolescents prescribed risperidone compared with aripiprazole had a significantly greater length of stay (9.7 days vs. 5.8 days, p = 0.002) and length of stay index (1.4 vs. 0.79, p = 0.004). Conclusions: Adolescents hospitalized for co-occurring psychosis and cannabis use disorder had a significantly longer length of stay and length of stay index. These data are consistent with a more rapid reduction in acute psychotic symptoms for aripiprazole compared with risperidone in the context of co-occurring cannabis use disorder.

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来源期刊
CiteScore
3.60
自引率
5.30%
发文量
61
审稿时长
>12 weeks
期刊介绍: Journal of Child and Adolescent Psychopharmacology (JCAP) is the premier peer-reviewed journal covering the clinical aspects of treating this patient population with psychotropic medications including side effects and interactions, standard doses, and research on new and existing medications. The Journal includes information on related areas of medical sciences such as advances in developmental pharmacokinetics, developmental neuroscience, metabolism, nutrition, molecular genetics, and more. Journal of Child and Adolescent Psychopharmacology coverage includes: New drugs and treatment strategies including the use of psycho-stimulants, selective serotonin reuptake inhibitors, mood stabilizers, and atypical antipsychotics New developments in the diagnosis and treatment of ADHD, anxiety disorders, schizophrenia, autism spectrum disorders, bipolar disorder, eating disorders, along with other disorders Reports of common and rare Treatment Emergent Adverse Events (TEAEs) including: hyperprolactinemia, galactorrhea, weight gain/loss, metabolic syndrome, dyslipidemia, switching phenomena, sudden death, and the potential increase of suicide. Outcomes research.
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