铁藻通过调节哮喘大鼠细胞因子的产生对过敏性哮喘的治疗作用

IF 1.5 4区生物学 Q3 PLANT SCIENCES

Turkish Journal of Botany Pub Date : 2021-12-31 DOI:10.3906/bot-2111-22

Poonam Arora

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引用次数: 4

摘要

在本研究中，在卵清蛋白诱导的哮喘小鼠模型中，研究了铁花雄蕊的乙醇提取物逆转支气管哮喘某些特征的潜力。铁藻（Mesua ferrea）通常被称为nagakeshar（海藻科），是亚洲民间药物体系中一种著名的抗过敏药物。在本工作中，进行了药理学研究，为植物治疗过敏性哮喘的潜力提供了科学证据。用卵清蛋白和氢氧化铝的过敏原悬浮液诱导实验大鼠哮喘，然后用地塞米松（2.5 mg/kg，p.o）或铁藻雄蕊提取物（3.75和15 mg/kg，b.w.，p.o，检测血液和支气管（BAL）液中的亚硝酸盐浓度、白三烯（LT）-D-4和亚硝酸盐浓度。哮喘动物和治疗动物的肺功能评估为呼吸频率和潮气量。铁藻雄蕊提取物（MFE）治疗显著（p＜0.001、p＜0.01和p＜0.05）减少了血液/血清和支气管液中炎症细胞、IgE、细胞因子和亚硝酸盐的浸润。MFE治疗后哮喘动物肺功能的改善（p<0.05）也支持我们的研究结果。研究结果表明，铁藻在过敏性哮喘中具有治疗潜力，这可能与植物减弱炎症细胞反应的能力有关，从而减少气道中炎症和促炎细胞因子的产生。

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Mesua ferrea L. (Calophyllaceae) exerts therapeutic effects in allergic asthma by modulating cytokines production in asthmatic rats

: In the present study, ethanolic extract of Mesua ferrea L. stamens was investigated for its potential to reverse some features of bronchial asthma in ovalbumin-induced murine model of asthma. Mesua ferrea commonly called nagakeshar (Family, Calophyllaceae) is a well-known antiallergic drug in the Asian folk system of medicines. In the present work, pharmacological studies are done to provide scientific evidence for therapeutic potential of plants in allergic asthma. Asthma was induced in experimental rats with allergen suspension of ovalbumin and aluminium hydroxide followed by treatment with dexamethasone (2.5 mg/kg, p.o) or M. ferrea stamen extract (3.75 and 15 mg/kg, b.w., p.o). Biomarkers of inflammatory response including cell counts, Immunoglobulin E, cytokines such as interleukin (IL)-4, -5, -1 β , tumor necrosis factor (TNF)- α , leukotriene (LT)-D-4, and nitrite concentration in blood as well as bronchial (BAL) fluid were tested. Lung functions in asthmatic and treated animals were evaluated as breathing rate and tidal volume. Treatment with M. ferrea stamen extract (MFE) markedly (p < 0.001, p < 0.01 and p < 0.05) diminished infiltration of inflammatory cells, IgE, cytokines, and nitrites in blood/serum and bronchial fluid. Improvement in lung functions (p < 0.05) of asthmatic animals after MFE treatment also supports our findings. Results of the study suggest a therapeutic potential of M. ferrea in allergic asthma that can be related to the ability of plants to attenuate the response of inflammatory cells and thereby, the production of inflammatory and proinflammatory cytokines in airways.

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来源期刊

Turkish Journal of Botany PLANT SCIENCES-

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The Turkish Journal of Botany is published electronically 6 times a year by the Scientific and Technological Research Council of Turkey (TÜBİTAK) and accepts manuscripts (in English) covering all areas of plant biology (including genetics, evolution, systematics, structure, function, development, diversity, conservation biology, biogeography, paleobotany, ontogeny, functional morphology, ecology, reproductive biology, and pollination biology), all levels of organisation (molecular to ecosystem), and all plant groups and allied organisms (algae, fungi, and lichens). Authors are required to frame their research questions and discuss their results in terms of major questions in plant biology. In general, papers that are too narrowly focused, purely descriptive, or broad surveys, or that contain only preliminary data or natural history, will not be considered (*). The following types of article will be considered: 1. Research articles: Original research in various fields of botany will be evaluated as research articles. 2. Research notes: These include articles such as preliminary notes on a study or manuscripts on the morphological, anatomical, cytological, physiological, biochemical, and other properties of plant, algae, lichen and fungi species. 3. Reviews: Reviews of recent developments, improvements, discoveries, and ideas in various fields of botany. 4. Letters to the editor: These include opinions, comments relating to the publishing policy of the Turkish Journal of Botany, news, and suggestions. Letters should not exceed one journal page. (*) 1. Raw floristic lists (of algae, lichens, fungi, or plants), species descriptions, chorological studies, and plant sociology studies without any additional independent approaches. 2. Comparative morphology and anatomy studies (that do not cover a family, tribe, subtribe, genus, subgenus, section, subsection, or species complexes with taxonomical problems) without one or more independent additional approaches such as phylogenetical, micromorphological, chromosomal and anatomical analyses. 3. Revisions of family, tribe, genus, subgenus, section, subsection, or species complexes without any original outputs such as taxonomical status changes, IUCN categories, and phenological and ecological analyses. 4. New taxa of all plants without any additional independent approaches such as phylogenetical, ecological, chromosomal, chorological and correlational analyses in addition to a detailed macro- and micro-morphological descriptions with quality field and microscopic illustrations of taxonomically important structures and identification key in the taxonomic group. New records of all plants without any additional independent approaches such as phylogenetical, ecological, chromosomal, chorological and correlational analyses in addition to a detailed macro- and micro-morphological descriptions with quality field and microscopic illustrations of taxonomically important structures and identification key in the taxonomic group may be accepted for peer review if they contain 3 or more new records or taxonomical status update, such as lectotypification, new combinations, transfers, revivals and synonyms. 5. New taxa of algae, lichens, and fungi without any additional independent approaches such as phylogenetical, ecological, chromosomal, chorological and correlational analyses in addition to a detailed macro- and micro-morphological descriptions with quality field and microscopic illustrations of taxonomically important structures and identification key in the taxonomic group. New records of algae, lichens, and fungi without any additional independent approaches such as phylogenetical, ecological, chromosomal, chorological and correlational analyses in addition to a detailed macro- and micro-morphological descriptions with quality field and microscopic illustrations of taxonomically important structures and identification key in the taxonomic group may be accepted for peer review if they contain 5 or more new records or taxonomical status update, such as lectotypification, new combinations, transfers, revivals and synonyms.