孕妇红细胞血型不规则抗体的产前筛查与鉴定

国际输血及血液学杂志 Pub Date : 2020-01-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2020.01.012

B. Han, Yuli Zhu

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引用次数: 0

摘要

目的探讨孕妇红细胞血型不规则抗体的分布特点。方法选择2016年1月至2018年6月在青岛血液中心进行红细胞血型不规则抗体检测的130名孕妇为受试者。孕妇的年龄为25-42岁，中位年龄为32岁。用试管法测定孕妇ABO和Rh血型，Rh血型系统抗体滴度不规则。红细胞血型不规则抗体的筛选和鉴定采用微柱凝胶凝集法或试管试验法。本研究遵循的程序符合2013年修订的《世界医学会赫尔辛基宣言》的要求。并获得了所有受试者的知情同意。结果①130例孕妇中，A、B、O、AB血型分别为44例（33.8%）、48例（36.9%）、27例（20.8%）和11例（8.5%）。Rh阳性90例（69.2%），Rh阴性40例（30.8%）在130例孕妇血清中，Rh、MNSs、P和Lewis血型分别为71例（54.6%）、28例（21.5%）、3例（2.3%）和14例（10.8%），抗HI抗体为4例（3.1%）在检测到Rh血型系统不规则抗体的71名孕妇中，检测率最高的抗体滴度为2，检测率为26.8%（19/71）。一名孕妇的抗体滴度为512。她的Rh血型为Rh阴性。她之前接受过RhD阳性红细胞的输血。结论青岛市红细胞血型不规则抗体阳性孕妇的抗体分布以Rh血型为主，MNSs血型次之。产前筛查和鉴定孕妇红细胞血型不规则抗体，有利于保证孕妇输血安全，降低新生儿溶血病（HDN）的发生风险。关键词：血型抗原；抗体；孕妇；红细胞增多症，胎儿；输血；Rh-Hr血型系统；MNSs血型系统；不规则抗体

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Prenatal screening and identification of irregular antibodies of erythrocyte blood type in pregnant women

Objective To investigate the distribution and characteristics of irregular antibodies of erythrocyte blood type in pregnant women. Methods From January 2016 to June 2018, a total of 130 pregnant women who were identified for irregular antibodies of erythrocyte blood type in Qingdao Blood Center, were selected as the subjects. The age of the pregnant women was 25-42 years, and the median age was 32 years. ABO and Rh blood group identification of pregnant women, and irregular antibody titers of Rh blood group system were determined by test tube method. The screening and identification of irregular antibodies of erythrocyte blood type were used micro-column gel agglutination or tube test method. The procedure followed in this study was in line with the requirements of the revised World Medical Association Declaration of Helsinki in 2013. And informed consents were obtained from all the subjects. Results ① Among the 130 pregnant women, there were 44 cases (33.8%) , 48 cases (36.9%) , 27 cases (20.8%) and 11 cases (8.5%) of blood group A、B、O and AB, respectively. And 90 cases (69.2%) were Rh positive and 40 cases (30.8%) were Rh negative blood group. ② Among the serum samples of 130 pregnant women, 71 cases (54.6%) , 28 cases (21.5%), 3 cases (2.3%) and 14 cases (10.8%) were in Rh, MNSs, P and Lewis blood group system respectively, and 4 cases (3.1%) were anti-HI. ③ Among 71 pregnant women who were detected irregular antibodies of Rh blood group system, antibody titer with the highest detection rate was 2, whose detection rate was 26.8% (19/71). One pregnant woman had an antibody titer of 512. Her Rh blood group was Rh negative. And she had previously received RhD positive red blood cells transfusion. Conclusions In Qingdao City, the irregular antibody distribution in pregnant women with positive irregular antibodies of erythrocyte blood type is dominated by the Rh blood system, followed by the MNSs blood system. Prenatal screening and identification of irregular antibodies of erythrocyte blood group in pregnant women is conducive to ensure the safety of pregnant women′s blood transfusion and reducing the risk of hemolytic disease of newborn (HDN). Key words: Blood group antigens; Antibodies; Pregnant woman; Erythroblastosis, fetal; Blood transfusion; Rh-Hr blood-group system; MNSs blood-group system; Irregular antibody

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来源期刊

国际输血及血液学杂志

自引率

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发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.