病灶内曲安奈德与自体富血小板血浆治疗斑秃的临床疗效和毛发检查变化的比较

Warood Albadri, A. Inamadar
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引用次数: 0

摘要

背景:斑秃(AA)是一种自身免疫性疾病,影响头皮和身体,导致脱发。管理的根本目标是控制病理。病灶内皮质类固醇抑制T细胞介导的对毛囊的攻击。富含血小板的血浆(PRP)含有刺激毛囊干细胞的生长因子,具有抗炎特性,副作用较少。毛发镜检查显示急性期有感叹毛和黑点,长期病例有黄点,再生斑块有短绒毛。目的:本研究的目的是评估和比较病变内曲安奈德和自体PRP治疗同一个体两种不同头皮AA贴片的疗效。材料和方法:这是一项基于医院的前瞻性随访研究。选择了两种不同类型脱发的患者。一个用病灶内曲安奈德(10 mg/ml)治疗,另一个用PRP治疗,间隔3周,共4个疗程。结果的比较基于MacDonald-Hull和Norris分级系统以及毛发检查。结果:在32名患者中,8名(25%)接受曲安奈德治疗的贴片和3名(9.4%)接受PRP治疗的贴片在12周时显示毛发完全再生。此外,曲安奈德的反应更快。在毛发镜检查中,这两种贴片都显示出短毛和顶毛的增加,黄点和感叹毛的减少。黑点没有变化。结论:曲安奈德对头皮AA的治疗效果优于PRP,且安全。毛镜检查结果表明对治疗有反应,疾病活动减少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of clinical efficacy and trichoscopic changes in alopecia areata of the scalp following treatment with intralesional triamcinolone acetonide and autologous platelet-rich plasma
Background: Alopecia areata (AA) is an autoimmune disease affecting the scalp and body, resulting in hair loss. The fundamental goal of management is to keep the pathology under control. Intralesional corticosteroids suppress T-cell-mediated attacks on hair follicles. Platelet-rich plasma (PRP) contains growth factors that stimulate hair follicle stem cells and have anti-inflammatory properties with fewer side effects. Trichoscopy shows exclamation hair and black dots in the acute stage, yellow dots in long-standing cases, and short vellus hair in regrowing patches. Objective: The aim of this study was to evaluate and compare the efficacy of intralesional triamcinolone acetonide with autologous PRP in the treatment of two different scalp AA patches in the same individual. Materials and Methods: This was a hospital-based prospective follow-up study. Patients with two different patches of alopecia were selected. One was treated with intralesional triamcinolone acetonide (10 mg/ml) and the other with PRP given at 3-week intervals for four treatment sessions. Comparison of results was based on MacDonald Hull and Norris grading system and trichoscopy. Results: Out of 32 patients, 8 (25%) in triamcinolone-treated patches and 3 (9.4%) in PRP-treated patches showed complete hair regrowth at 12 weeks. Furthermore, a faster response was seen with triamcinolone. On trichoscopy, both patches showed an increase in short vellus and terminal hair and a reduction in yellow dots and exclamation hair. No changes in black dots were seen. Conclusion: Intralesional triamcinolone acetonide is more effective than PRP in the treatment of AA of the scalp and is safe. Trichoscopic findings indicate response to treatment and reduction of disease activity.
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