丁螺环酮改善胃食管反流病和无效食管动力患者吞咽困难的疗效评价:一项随机临床试验

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY
Foroogh Alborzi Avanaki, Elham Baghereslami, H. A. Varpaei, Narges Farhadi, N. Aletaha, Farshad Allameh, M. Taher
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引用次数: 0

摘要

背景:在测压评估中,无效食管运动(IEM)是最常见的食管运动障碍,与食管远端低至中等幅度收缩有关。尽管最近有关于食管运动和IEM的病理生理学的新概念,但仍然没有有效的治疗干预措施来治疗这种疾病。本研究旨在探讨丁螺环酮治疗合并IEM和GERD的疗效。方法和材料:本研究是在德黑兰伊玛目霍梅尼医院进行的随机临床试验。有胃食管反流病史和吞咽困难的患者接受了上内镜检查,以排除任何机械性梗阻,并根据高分辨率测压法诊断为无效的食管运动障碍。他们得到了一个装有所需药物的包裹;一半的包含有10毫克(持续30天)丁螺环酮和40毫克(持续三十天)泮托拉唑,另一半只含有40毫克(30天)泮托拉唑。吞咽困难根据Mayo评分以及吞咽困难严重程度表进行评分。在治疗前后记录测压变量。结果:纳入30例患者(15例泮托拉唑和15例泮托拉唑加丁螺环酮)。女性占总人口的63.3%,平均年龄为46.33±11.15岁。MAYO评分和静息LES压力在治疗后有显著变化。两组患者的MAYO和吞咽障碍问卷得分在治疗后均显著下降。我们的结果显示,在控制了变量的基线值后,两组之间的测压变量的干预后值存在显著差异。该分析并未证明丁螺环酮的优越性。结论:丁螺环酮似乎没有PPI的优势。同时使用质子泵抑制剂进行IEM和GERD治疗可改善患者的临床状况和生活质量。然而,在治疗方案中加入丁螺环酮似乎对患者的治疗没有显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Therapeutic Effect of Buspirone in Improving Dysphagia in Patients with GERD and Ineffective Esophageal Motility: A Randomized Clinical Trial
Background: Ineffective esophageal motility (IEM) is the most common esophageal motility disorder associated with low-to-moderate amplitude contractions in the distal esophagus in manometric evaluations. Despite recent new conceptions regarding the pathophysiology of esophageal motility and IEM, there are still no effective therapeutic interventions for the treatment of this disorder. This study aimed to investigate the effect of buspirone in the treatment of concomitant IEM and GERD. Methods and Materials: The present study was a randomized clinical trial conducted at the Imam Khomeini Hospital, Tehran. Patients with a history of gastroesophageal reflux disease and dysphagia underwent upper endoscopy to rule out any mechanical obstruction and were diagnosed with an ineffective esophageal motility disorder based on high-resolution manometry. They were given a package containing the desired medication(s); half of the packets contained 10 mg (for 30 days) of buspirone and 40 mg (for 30 days) of pantoprazole, and the other half contained only 40 mg (for 30 days) of pantoprazole. Dysphagia was scored based on the Mayo score, as well as a table of dysphagia severity. Manometric variables were recorded before and after the treatment. Results: Thirty patients (15 pantoprazole and 15 pantoprazole plus buspirone) were included. Females comprised 63.3% of the population, with a mean age of 46.33 ± 11.15. The MAYO score and resting LES pressure significantly changed after treatment. The MAYO and Swallowing Disorder Questionnaire scores significantly decreased after treatment in both groups of patients. Our results revealed that the post-intervention values of manometric variables differed significantly between the two groups after controlling for the baseline values of the variables. This analysis did not demonstrate the superiority of buspirone. Conclusion: Buspirone seems to have no superiority over PPI. Treatment with concomitant IEM and GERD using proton pump inhibitors improves the patient’s clinical condition and quality of life. However, adding buspirone to the treatment regimen did not appear to make a significant difference in patient treatment.
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来源期刊
Gastroenterology Insights
Gastroenterology Insights GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
2.80
自引率
3.40%
发文量
35
审稿时长
10 weeks
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