含乳酸-壳聚糖复合物的海藻酸钠对亲水性微球的评价

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2021-09-30 DOI:10.15259/pcacd.26.015

K. Małolepsza-Jarmołowska

{"title":"含乳酸-壳聚糖复合物的海藻酸钠对亲水性微球的评价","authors":"K. Małolepsza-Jarmołowska","doi":"10.15259/pcacd.26.015","DOIUrl":null,"url":null,"abstract":"An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.","PeriodicalId":44461,"journal":{"name":"Progress on Chemistry and Application of Chitin and its Derivatives","volume":" ","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"EVALUATION OF HYDROPHILIC GLOBULES WITH SODIUM ALGINATE CONTAINING A LACTIC ACID– CHITOSAN COMPLEX\",\"authors\":\"K. Małolepsza-Jarmołowska\",\"doi\":\"10.15259/pcacd.26.015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.\",\"PeriodicalId\":44461,\"journal\":{\"name\":\"Progress on Chemistry and Application of Chitin and its Derivatives\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2021-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress on Chemistry and Application of Chitin and its Derivatives\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15259/pcacd.26.015\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress on Chemistry and Application of Chitin and its Derivatives","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15259/pcacd.26.015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

摘要

治疗阴道炎的一个重要问题是药物在阴道粘膜上停留的时间。如果接触时间太短，药物就无法有效地确保阴道环境中的pH值正确。本研究评估了含有海藻酸钠、乳酸和壳聚糖的具有不同pH和流变特性的球蛋白制剂。实验研究表明，制备具有最佳药物和应用性能的制剂是可能的。在复合物中使用适当比例的乳酸与壳聚糖以及适当浓度的藻酸钠，可以制备出具有优异性能的制剂来覆盖阴道粘膜表面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

EVALUATION OF HYDROPHILIC GLOBULES WITH SODIUM ALGINATE CONTAINING A LACTIC ACID– CHITOSAN COMPLEX

An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.