血清Vit。糖尿病肾病伊拉克患者的D和肾功能

mjl@ kly@ lTb Pub Date : 2023-07-01 DOI:10.32007/jfacmedbagdad.1979

Nadia Alewe Mijbel, Shafa Jamil Ibrahim

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引用次数: 0

摘要

背景：根据几项动物和人类研究，维生素D似乎在糖尿病肾病的发展中发挥着重要作用。然而，维生素D的雷诺保护作用和对逆转现有肾损伤的影响的可能性仍然是推测性的。维生素D缺乏和不足在世界各地普遍存在，并与多种病理生理状况有关，包括糖尿病、过敏、自身免疫性疾病、妊娠困难，以及最近更严重的新冠肺炎临床结果。从翻译的角度来看，这篇综述的目的是探讨维生素D在糖尿病肾病发展中的潜在功能。研究目的：评估维生素D的作用。D对DMT1患者肾功能的影响。患者和方法：研究参与者总数为120人，分为三组：A组：包括40名患有糖尿病伴NP的患者（1期、2期、3a期），B组包括40名无NP的糖尿病患者，C组包括40例健康参与者（对照）。在2021年10月至2022年3月期间，从内分泌和糖尿病中心/Al Kindy医院、巴格达教学医院/医疗城和Al Shaheed Al Sadder综合医院的糖尿病控制诊所采集样本。结果：维生素D与肾小球滤过率之间存在统计学显著的弱正相关（r=0.321，P=0.001）；维生素D与HbA1c呈中度负相关（r=-0.494，P=0.001），与尿素双歧杆菌呈弱负相关（r=-0.2，P=0.028）。结论：我们的数据表明维生素D3水平降低与糖尿病肾病之间存在相关性，它可能是糖尿病肾病发生和严重程度的潜在预测指标

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The Relationship between Levels of Serum Vit. D and Kidney Function in Diabetic Nephropathy Iraqi Patient

Background: According to several animal and human studies, Vitamin D appears to play a substantial role in the development of diabetic nephropathy, However, the possibility of vitamin D's Reno protective impact and influence on the reversal of already-existing renal damage remains speculative. Vitamin D deficiency and insufficiency are ubiquitous worldwide and have been linked to a variety of pathophysiological conditions, including diabetes, allergies, autoimmune illnesses, pregnancy difficulties, and, more recently, worse COVID-19 clinical outcomes. From a translational perspective, the goal of this review is to look into the potential function of vitamin D in the development of diabetic kidney diseases Aim of the study: to evaluate the role of vit. D on renal function in patients with DMT1. Patient and Method: The total number of study participants was 120, divided into three groups: Group A: Included 40 patients have DM with NP (stage1, stage 2, stage 3a), Group B included 40 patients who had DM without NP, and group C included 40 healthy participants (control). Samples were taken from the Diabetic control clinic of Endocrinology and Diabetes Center/Al-Kindy Hospital, Baghdad Teaching Hospital/ Medical City, and Al-Shaheed Al-Sadder General Hospital during the period from October 2021 to March 2022. Result: Statistically significant weak positive correlations were detected between vitamin D and GFR (r= 0.321, P= 0.001); while a significant moderate negative correlation was seen between vitamin D and HbA1c (r= -0.494, P= 0.001) and weak negative correlation was seen with B. Urea (r= -0.2, P= 0.028). No statistically significant correlations were detected between vitamin D and all of age, DM duration, and s. creatinine. Conclusion: Our data suggest a correlation between reduced levels of vitamin D3 and diabetes nephropathy and it may be a potential predictor for both the occurrence and severity of diabetic nephropathy

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mjl@ kly@ lTb

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24 weeks