4-（戊氧基）-7-（丙-2-炔-1-基氧基）蝶呤-2-胺的合成、表征及氯化反应

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-07-08 DOI:10.3390/m1692

Jevy V. Correia, Bruno Wilke, C. Schulzke

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引用次数: 0

摘要

在氢化钠存在下，7-氯蝶呤与炔丙醇反应，合成了一种新的炔官能化蝶呤衍生物。通过NMR（1H，13C）光谱、质谱（APCI源）光谱、元素分析和X射线晶体学验证了化合物的纯度和化学结构。标题化合物可以通过利用炔部分进一步官能化，例如使用点击化学。新的蝶呤衍生物，最值得注意的是，与典型的蝶呤行为相反，现在几乎在除水之外的任何溶剂中都是可溶的，甚至是完全可溶的。

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Synthesis, Characterization and Chlorination of 4-(Pentyloxy)-7-(prop-2-yn-1-yloxy)pteridin-2-amine

A new alkyne functionalized pterin derivative was synthesized through a reaction of 7-chloropterin with propargyl alcohol in the presence of sodium hydride. The purity and chemical structure of the compound was validated by NMR (1H, 13C) spectroscopy, Mass (APCI source) spectrometry, elemental analysis, and X-ray crystallography. The title compound may be further functionalized by exploiting the yne moiety, for instance, using click chemistry. The novel pterin derivative, most notably, in contrast to typical pterin behavior, is now soluble or even well soluble in almost any solvent except water.

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)