Mania Induced by a Single Dose of Synthetic Cannabinoid

Synthetic cannabinoids (SCs) are substances with chemical structures that comprise a family of compounds and have structures that can bind to cannabinoid receptors in human cells known as CB1 or CB2. Most SCs are stronger than tetrahydrocannabinol and pose a greater health risk. In this article, we present a mania case that was triggered by a single dose of the SC Bonzai and registered improvement after longterm inpatient treatment. In the literature, only one previous case has been reported of a manic attack induced by SC, and this previously reported case had manic symptoms that started after 6months of SC use. In our case, we aimed to discuss the possible mechanisms of SC use, which may cause affective symptoms and a serious psychotic manic episode even in the absence of long-term exposure.