HT29细胞系靶向固体脂质纳米粒子治疗结肠癌及其细胞毒性评价

IF 1 Q4 PHARMACOLOGY & PHARMACY

Jundishapur Journal of Natural Pharmaceutical Products Pub Date : 2023-05-06 DOI:10.5812/jjnpp-135987

E. Moghimipour, M. Abedini, S. Handali

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引用次数: 0

摘要

背景：百里酚具有多种药理作用。然而，诸如在水中的低溶解度、低生物利用度和高挥发性等限制了其使用。目的：本研究旨在制备和表征胸腺素负载的固体脂质纳米颗粒（SLNs），以提高胸腺素的疗效。方法：采用原子力显微镜（AFM）、差示扫描量热法（DSC）和傅立叶变换红外光谱（FT-IR）对胸腺素负载的SLNs进行表征。还进行了细胞毒性研究和溶血试验。结果：药物体外释放呈持续性。此外，负载百里香酚的SLNs表现出比游离百里香醇更高的细胞毒性，溶血结果表明了SLNs的血液生物相容性。结论：SLNs作为纳米载体，可为提高百里香酚治疗癌症的疗效开辟新的途径。

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Targeted Solid Lipid Nanoparticles Formulation for Colon Cancer Treatment and Cytotoxicity Assessment Using HT29 Cell Line

Background: Several pharmacological effects have been attributed to thymol. However, limitations such as low solubility in water, low bioavailability, and high volatility have limited its use. Objectives: The present study aimed to prepare and characterize thymol-loaded solid lipid nanoparticles (SLNs) to improve the efficacy of thymol. Methods: Thymol-loaded SLNs were characterized by atomic force microscopy (AFM), differential scanning calorimetry (DSC), and Fourier transformed infrared spectroscopy (FT-IR). Cytotoxicity study and hemolysis assay were also performed. Results: The in vitro drug release showed a sustained manner. Also, SLNs loaded with thymol showed higher cytotoxicity than free thymol, and the hemolysis results indicated the blood biocompatibility of SLNs. Conclusions: As nanocarriers, SLNs can open a new avenue for improving the efficacy of thymol in cancer treatment.

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来源期刊

Jundishapur Journal of Natural Pharmaceutical Products PHARMACOLOGY & PHARMACY-

CiteScore

1.40

自引率

0.00%

发文量