绿原酸改善小鼠糖尿病相关肌萎缩

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Xianchu Liu, Ming-xue Liu
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引用次数: 0

摘要

糖尿病与肌肉功能障碍密切相关。绿原酸对糖尿病并发症具有多种治疗作用。然而,没有研究表明CGA对糖尿病相关肌萎缩有改善作用。在本研究中,链脲佐菌素(STZ)建立了糖尿病模型,以评估CGA(30mg/kg/d,持续8周)在糖尿病相关肌萎缩中的作用。我们的研究表明,CGA增强了具有代表性的肌细胞横截面、腓肠肌重量和握力。在血清中,CGA抑制CK、LDH、MDA、TNF-a和IL-6水平,同时提高T-ACO、SOD和CAT水平以对抗糖尿病引起的肌肉损伤。在骨骼肌中,CGA增加BCL-2的表达,同时减少FBXO-32、MURF-1、DDIT-3、GRP-87和BAX的表达,以改善糖尿病性肌萎缩。总之,CGA通过其对内质网应激和细胞凋亡的调节的生物活性来保护糖尿病相关肌萎缩,并且可能是改善糖尿病肌萎缩的有力治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chlorogenic acid improves diabetes-associated muscular atrophy in mice
Diabetes is closely relevant to muscle dysfunction. Chlorogenic acid (CGA) possesses various therapeutic functions in diabetic complications. However, no research implied the amelioration of CGA on diabetes-associated muscular atrophy. In this study, diabetic model was established by streptozotocin (STZ) to appraise roles of CGA (30 mg/kg/d for 8 weeks) on diabetes-associated muscular atrophy. Our researches demonstrated that CGA enhanced representative myocyte cross-sections, gastrocnemius weight and grip strength. In serum, CGA restricted CK, LDH, MDA, TNF-a and IL-6 levels, while elevated T-ACO, SOD and CAT levels against diabetic-evoked muscle damage. In skeletal muscle, CGA increased BCL-2 expression, while reduced FBXO-32, MURF-1, DDIT-3, GRP-87 and BAX expressions to improve diabetic muscular atrophy. In conclusion, CGA protected from diabetic-associated muscular atrophy through its bioactivities on the regulation of endoplasmic reticulum stress and apoptosis, and could be a powerful remedy approach in the ameliorations of diabetic muscle atrophy.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.
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