{"title":"绿原酸改善小鼠糖尿病相关肌萎缩","authors":"Xianchu Liu, Ming-xue Liu","doi":"10.32383/appdr/158786","DOIUrl":null,"url":null,"abstract":"Diabetes is closely relevant to muscle dysfunction. Chlorogenic acid (CGA) possesses various therapeutic functions in diabetic complications. However, no research implied the amelioration of CGA on diabetes-associated muscular atrophy. In this study, diabetic model was established by streptozotocin (STZ) to appraise roles of CGA (30 mg/kg/d for 8 weeks) on diabetes-associated muscular atrophy. Our researches demonstrated that CGA enhanced representative myocyte cross-sections, gastrocnemius weight and grip strength. In serum, CGA restricted CK, LDH, MDA, TNF-a and IL-6 levels, while elevated T-ACO, SOD and CAT levels against diabetic-evoked muscle damage. In skeletal muscle, CGA increased BCL-2 expression, while reduced FBXO-32, MURF-1, DDIT-3, GRP-87 and BAX expressions to improve diabetic muscular atrophy. In conclusion, CGA protected from diabetic-associated muscular atrophy through its bioactivities on the regulation of endoplasmic reticulum stress and apoptosis, and could be a powerful remedy approach in the ameliorations of diabetic muscle atrophy.","PeriodicalId":7147,"journal":{"name":"Acta poloniae pharmaceutica","volume":" ","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chlorogenic acid improves diabetes-associated muscular atrophy in mice\",\"authors\":\"Xianchu Liu, Ming-xue Liu\",\"doi\":\"10.32383/appdr/158786\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Diabetes is closely relevant to muscle dysfunction. Chlorogenic acid (CGA) possesses various therapeutic functions in diabetic complications. However, no research implied the amelioration of CGA on diabetes-associated muscular atrophy. In this study, diabetic model was established by streptozotocin (STZ) to appraise roles of CGA (30 mg/kg/d for 8 weeks) on diabetes-associated muscular atrophy. Our researches demonstrated that CGA enhanced representative myocyte cross-sections, gastrocnemius weight and grip strength. In serum, CGA restricted CK, LDH, MDA, TNF-a and IL-6 levels, while elevated T-ACO, SOD and CAT levels against diabetic-evoked muscle damage. In skeletal muscle, CGA increased BCL-2 expression, while reduced FBXO-32, MURF-1, DDIT-3, GRP-87 and BAX expressions to improve diabetic muscular atrophy. In conclusion, CGA protected from diabetic-associated muscular atrophy through its bioactivities on the regulation of endoplasmic reticulum stress and apoptosis, and could be a powerful remedy approach in the ameliorations of diabetic muscle atrophy.\",\"PeriodicalId\":7147,\"journal\":{\"name\":\"Acta poloniae pharmaceutica\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2023-01-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta poloniae pharmaceutica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.32383/appdr/158786\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta poloniae pharmaceutica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.32383/appdr/158786","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Chlorogenic acid improves diabetes-associated muscular atrophy in mice
Diabetes is closely relevant to muscle dysfunction. Chlorogenic acid (CGA) possesses various therapeutic functions in diabetic complications. However, no research implied the amelioration of CGA on diabetes-associated muscular atrophy. In this study, diabetic model was established by streptozotocin (STZ) to appraise roles of CGA (30 mg/kg/d for 8 weeks) on diabetes-associated muscular atrophy. Our researches demonstrated that CGA enhanced representative myocyte cross-sections, gastrocnemius weight and grip strength. In serum, CGA restricted CK, LDH, MDA, TNF-a and IL-6 levels, while elevated T-ACO, SOD and CAT levels against diabetic-evoked muscle damage. In skeletal muscle, CGA increased BCL-2 expression, while reduced FBXO-32, MURF-1, DDIT-3, GRP-87 and BAX expressions to improve diabetic muscular atrophy. In conclusion, CGA protected from diabetic-associated muscular atrophy through its bioactivities on the regulation of endoplasmic reticulum stress and apoptosis, and could be a powerful remedy approach in the ameliorations of diabetic muscle atrophy.
期刊介绍:
The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General.
A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.