James Riddell IV , Andrew F. Brouwer , Heather M. Walline , Lora P. Campredon , Rafael Meza , Marisa C. Eisenberg , Emily C. Andrus , Rachel L. Delinger , Monica L. Yost , Jodi K. McCloskey , Trey B. Thomas , Suiyuan Huang , Robert L. Ferris , Dong Moon Shin , Carole Fakhry , Thomas Ow , Daniel Li , Ashley Berlot , Thomas E. Carey , Nicolas F. Schlecht
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DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes.</p></div><div><h3>Results</h3><p>Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study.</p></div><div><h3>Conclusions</h3><p>Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.</p></div>","PeriodicalId":52381,"journal":{"name":"Tumour Virus Research","volume":null,"pages":null},"PeriodicalIF":4.7000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666679022000039/pdfft?md5=2bfb47919a1a953e7a6dd2904527ecb2&pid=1-s2.0-S2666679022000039-main.pdf","citationCount":"4","resultStr":"{\"title\":\"Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults\",\"authors\":\"James Riddell IV , Andrew F. Brouwer , Heather M. Walline , Lora P. Campredon , Rafael Meza , Marisa C. Eisenberg , Emily C. Andrus , Rachel L. Delinger , Monica L. Yost , Jodi K. McCloskey , Trey B. Thomas , Suiyuan Huang , Robert L. Ferris , Dong Moon Shin , Carole Fakhry , Thomas Ow , Daniel Li , Ashley Berlot , Thomas E. Carey , Nicolas F. Schlecht\",\"doi\":\"10.1016/j.tvr.2022.200237\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls.</p></div><div><h3>Methods</h3><p>101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3–8 months over a period of 2 years (2015–2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes.</p></div><div><h3>Results</h3><p>Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study.</p></div><div><h3>Conclusions</h3><p>Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.</p></div>\",\"PeriodicalId\":52381,\"journal\":{\"name\":\"Tumour Virus Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2022-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666679022000039/pdfft?md5=2bfb47919a1a953e7a6dd2904527ecb2&pid=1-s2.0-S2666679022000039-main.pdf\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tumour Virus Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666679022000039\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tumour Virus Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666679022000039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 4
摘要
hiv已被证明会增加口腔HPV感染的可能性。在这项研究中，我们评估了与HIV阴性对照相比，HIV感染患者口腔HPV的风险。方法从5个学术医疗中心招募健康成人志愿者(HIV-) 101例和成年HIV感染者(HIV+) 245例。在2年(2015-2017)期间，每3-8个月进行一次问卷调查和唾液样本采集。从唾液样本中分离出DNA，并对18种高风险和低风险基因型进行了测试。结果23%的HIV阳性组和10%的HIV阴性组检测到口腔HPV (p <0.0001)。男性口腔HPV患病率高于女性(27% vs 15% HIV+， p = 0.03, 16% vs 5% HIV-， p = 0.01)。HIV阳性参与者的风险因素包括更多的终生深吻和口交伴侣，以及艾滋病史。23%的HIV阳性患者和5%的HIV阴性患者检测到持续性口腔HPV (p <0.001)。在8名CD4计数为200细胞/μL的HIV阳性参与者中，没有人在研究期间清除HPV感染。结论在HIV阳性且HIV控制不良的成年人中，口腔HPV感染和持续的风险明显更高，这可能使他们患HPV相关癌症的风险增加。
Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults
Background
HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls.
Methods
101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Questionnaires and saliva samples were obtained every 3–8 months over a period of 2 years (2015–2017). DNA was isolated from the saliva samples and tested for 18 high- and low-risk genotypes.
Results
Oral HPV was detected in 23% of HIV + vs. 10% of HIV- participants (p < 0.0001). Men had a higher oral HPV prevalence than women (27% vs. 15% HIV+, p = 0.03, 16% vs. 5% HIV-, p = 0.01). Risk factors among HIV + participants included more lifetime deep kissing and oral sex partners, and history of AIDS. Persistent oral HPV was detected in 23% of HIV + vs. 5% of HIV- participants (p < 0.001). Among 8 HIV + participants with CD4 counts <200 cell/μL none had cleared their HPV infection during the study.
Conclusions
Risk of oral HPV infection and persistence was significantly higher in HIV + adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.
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