唾液、血清新蝶呤和白细胞介素6作为口腔和口咽鳞状细胞癌患者的生物标志物

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2022-01-01 DOI:10.1515/pteridines-2022-0045

Lenka Sasková, P. Tvrdý, B. Melichar, R. Pink, David Kral, P. Michl, Z. Dvořák

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引用次数: 0

摘要

摘要由于头颈部恶性肿瘤的发病率不断增加，对原发性疾病或癌前病变的早期诊断以及通过简单的非侵入性检测及时发现复发的医疗需求尚未得到满足。体液中生物标志物的分析可能适用于这一目标。在这篇综述中，我们比较了口腔和口咽鳞状细胞癌患者唾液和血浆/血清中新蝶呤和白细胞介素-6（IL-6）测量值的使用数据，表明使用唾液作为头颈癌诊断基质的适用性，有利于解剖学上的紧密接近，并有可能研究肿瘤微环境。柳新蝶呤和IL-6是癌症的潜在生物标志物，不仅适用于早期诊断，还适用于监测治疗结果和检测疾病复发。

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Salivary and serum neopterin and interleukin 6 as biomarkers in patients with oral and oropharyngeal squamous cell carcinoma

Abstract Because of an increasing incidence of malignant tumours of the head and neck there is an unmet medical need for early diagnosis of the primary disease or precancerous lesions, and timely detection of recurrence by simple non-invasive tests. The analysis of biomarkers in body fluids may be appropriate for this goal. In this review, we compare the data on utilization of neopterin and interleukin-6 (IL-6) measurements in saliva and plasma/serum of patients with oral and oropharyngeal squamous cell carcinoma, indicating the suitability of using saliva as a diagnostic matrix in head and neck cancers on behalf of close anatomical proximity and a potential to study the tumour microenvironment. Salivary neopterin and IL-6 are potential biomarkers of head and neck cancer suitable not only for early diagnosis, but also for monitoring of treatment results and detection of the disease recurrence.

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.