美国感染人类免疫缺陷病毒的顺性别女性中与病毒抑制相关的因素:一项综合综述

IF 2.7 Q2 OBSTETRICS & GYNECOLOGY
Titilola Labisi, A. Podany, N. Fadul, Jason D. Coleman, Keyonna M. King
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引用次数: 4

摘要

引言:在美国,女性占新诊断的人类免疫缺陷病毒的23%,但研究仍然不足。坚持抗逆转录病毒疗法和由此产生的病毒抑制是预防人类免疫缺陷病毒传播、降低耐药性风险和改善健康结果的关键。目的:这篇综述确定并综合了美国的同行评审研究,描述了感染人类免疫缺陷病毒的顺性别女性中与病毒抑制相关的因素。方法:我们检索了五个数据库:护理与联合健康累积指数(CINAHL)、PubMed、Embase、Scopus和PsycINFO,并使用系统评价首选报告项目和荟萃分析声明报告了研究结果。符合条件的研究包括:(1)自2010年以来发表的同行评审的英语文章;(2) 仅包括顺性别妇女;(3) 参与者年龄至少为18岁;(4) 报告的病毒载量指标;以及(5)在美国进行。结果:共回顾了14项研究。八项研究涉及感染人类免疫缺陷病毒的成年妇女,四项仅招募孕妇,两项仅包括少数民族妇女。最常见的与病毒抑制负相关的因素是物质使用(n = 4) ,其次是健康保险的可用性、财务限制、人类免疫缺陷病毒治疗方案的复杂性(n = 3) ,以及亲密伴侣暴力(n = 2) 。其他因素包括抑郁、种族和年龄。此外,所有四项仅包括孕妇的研究都报告称,早期人类免疫缺陷病毒护理是产前和产后低病毒载量的重要预测因素。结论:药物使用、经济拮据、缺乏医疗保险、人类免疫缺陷病毒治疗方案类型、亲密伴侣暴力和妊娠前后晚期人类免疫缺陷病毒护理是与病毒抑制呈负相关的最常见因素。关于与变性人和农村人口相关的病毒抑制因素的数据很少。需要进行更多的人体免疫缺陷病毒研究,以探索与美国农村地区跨性别女性和顺性别女性的人体免疫缺陷疫苗治疗结果相关的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors associated with viral suppression among cisgender women living with human immunodeficiency virus in the United States: An integrative review
Introduction: Women account for 23% of new human immunodeficiency virus diagnoses in the United States, yet remain understudied. Adherence to antiretroviral therapy and consequent viral suppression are keys to preventing human immunodeficiency virus transmission, reducing risk of drug resistance, and improving health outcomes. Objectives: This review identified and synthesized peer-reviewed studies in the United States describing factors associated with viral suppression among cisgender women living with human immunodeficiency virus. Methods: We searched five databases: Cumulative Index to Nursing and Allied Health (CINAHL), PubMed, Embase, Scopus, and PsycINFO, and reported the findings using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Eligible studies included: (1) peer-reviewed English-language articles published since 2010; (2) includes only cisgender women; (3) participants were at least 18 years of age; (4) reported metrics on viral loads; and (5) conducted in the United States. Results: Fourteen studies in total were reviewed. Eight studies had adult women living with human immunodeficiency virus, four recruited only pregnant women, and two included only racial minority women. The most commonly reported factors negatively associated with viral suppression were substance use (n = 4), followed by availability of health insurance, financial constraint, complexity of human immunodeficiency virus treatment regimen (n = 3), and intimate partner violence (n = 2). Other factors were depression, race, and age. In addition, all four studies that included only pregnant women reported early human immunodeficiency virus care engagement as a significant predictor of low viral loads pre- and post-partum. Conclusion: Substance use, financial constraint, lack of health insurance, human immunodeficiency virus treatment regimen type, intimate partner violence, and late human immunodeficiency virus care pre–post pregnancy were the most common factors negatively associated with viral suppression. There is a paucity of data on viral suppression factors related to transgender and rural populations. More human immunodeficiency virus research is needed to explore factors associated with human immunodeficiency virus treatment outcomes in transgender women and cisgender women in rural U.S. regions.
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来源期刊
Womens Health
Womens Health OBSTETRICS & GYNECOLOGY-
CiteScore
2.80
自引率
4.20%
发文量
0
审稿时长
15 weeks
期刊介绍: For many diseases, women’s physiology and life-cycle hormonal changes demand important consideration when determining healthcare management options. Age- and gender-related factors can directly affect treatment outcomes, and differences between the clinical management of, say, an adolescent female and that in a pre- or postmenopausal patient may be either subtle or profound. At the same time, there are certain conditions that are far more prevalent in women than men, and these may require special attention. Furthermore, in an increasingly aged population in which women demonstrate a greater life-expectancy.
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