外泌体微小RNA在癌症中的作用

Q1 Biochemistry, Genetics and Molecular Biology

Stem cell investigation Pub Date : 2020-02-28 DOI:10.21037/sci.2020.02.01

Yi-Fan Xu, Xiaohui Xu, A. Williams, W. Ding

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引用次数: 4

摘要

癌症是美国癌症死亡的第三大原因。迫切需要新的治疗和诊断策略来改善癌症的预后。外泌体是内泌体衍生的细胞外小泡，含有细胞脂质、蛋白质和微小RNA（miRNA）。研究表明，外泌体miRNA是各种类型癌症的潜在诊断生物标志物和治疗靶点。在这篇综述中，我们总结了最近的研究结果，表明外体miRNA在胰腺癌症进展、治疗耐药性和生物标志物开发中的作用。

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The role of exosomal microRNAs in pancreatic cancer

Pancreatic cancer is the third leading cause of cancer death in the United States. New therapeutic and diagnostic strategies are urgently needed to improve pancreatic cancer outcomes. Exosomes are endosome-derived extracellular vesicles containing cellular lipids, proteins, and microRNAs (miRNAs). Studies have shown that exosomal miRNAs are potential diagnostic biomarkers and therapeutic targets for various types of cancer. In this review, we summarize recent findings indicating the role of exosomal miRNAs in pancreatic cancer progression, therapeutic resistance, and biomarker development.

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来源期刊

Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

5.80

自引率

0.00%

发文量

期刊介绍： The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.