{"title":"氧化应激的细胞靶点","authors":"Lynette K. Rogers","doi":"10.1016/j.cotox.2020.05.002","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>There are three major sites of oxidant production in the cell; mitochondria, endoplasmic reticulum (ER), and </span>peroxisomes. Each is equipped with their own antioxidant system to prevent injury and protect subcellular functions. Mitochondria are essential to produce energy through </span>respiratory chain<span> activity and injury involves disruption of respiratory complexes and accelerated production and release of O2ˉ˙. ER is essential for protein processing and Ca</span></span><sup>2+</sup><span><span> homeostasis<span>, and interruption of ER functions results in upregulation of the unfolded protein response and initiation of </span></span>ER stress. Uncontrolled ER stress results in aberrant Ca</span><sup>2+</sup><span> regulation, production and release of reactive oxygen species, and activation of autophagy and apoptosis pathways. Peroxisomal function is tightly correlated to both mitochondria and ER and disruption precipitates release of H</span><sub>2</sub>O<sub>2</sub><span> into the cellular milieu. Drugs, environmental toxins, and aging all contribute to organelle injury and release of ROS, resulting in cardiovascular and neurological diseases and cancers.</span></p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"20 ","pages":"Pages 48-54"},"PeriodicalIF":6.1000,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2020.05.002","citationCount":"1","resultStr":"{\"title\":\"Cellular targets of oxidative stress\",\"authors\":\"Lynette K. Rogers\",\"doi\":\"10.1016/j.cotox.2020.05.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span><span>There are three major sites of oxidant production in the cell; mitochondria, endoplasmic reticulum (ER), and </span>peroxisomes. Each is equipped with their own antioxidant system to prevent injury and protect subcellular functions. Mitochondria are essential to produce energy through </span>respiratory chain<span> activity and injury involves disruption of respiratory complexes and accelerated production and release of O2ˉ˙. ER is essential for protein processing and Ca</span></span><sup>2+</sup><span><span> homeostasis<span>, and interruption of ER functions results in upregulation of the unfolded protein response and initiation of </span></span>ER stress. Uncontrolled ER stress results in aberrant Ca</span><sup>2+</sup><span> regulation, production and release of reactive oxygen species, and activation of autophagy and apoptosis pathways. Peroxisomal function is tightly correlated to both mitochondria and ER and disruption precipitates release of H</span><sub>2</sub>O<sub>2</sub><span> into the cellular milieu. Drugs, environmental toxins, and aging all contribute to organelle injury and release of ROS, resulting in cardiovascular and neurological diseases and cancers.</span></p></div>\",\"PeriodicalId\":37736,\"journal\":{\"name\":\"Current Opinion in Toxicology\",\"volume\":\"20 \",\"pages\":\"Pages 48-54\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2020-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.cotox.2020.05.002\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S246820202030036X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S246820202030036X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
There are three major sites of oxidant production in the cell; mitochondria, endoplasmic reticulum (ER), and peroxisomes. Each is equipped with their own antioxidant system to prevent injury and protect subcellular functions. Mitochondria are essential to produce energy through respiratory chain activity and injury involves disruption of respiratory complexes and accelerated production and release of O2ˉ˙. ER is essential for protein processing and Ca2+ homeostasis, and interruption of ER functions results in upregulation of the unfolded protein response and initiation of ER stress. Uncontrolled ER stress results in aberrant Ca2+ regulation, production and release of reactive oxygen species, and activation of autophagy and apoptosis pathways. Peroxisomal function is tightly correlated to both mitochondria and ER and disruption precipitates release of H2O2 into the cellular milieu. Drugs, environmental toxins, and aging all contribute to organelle injury and release of ROS, resulting in cardiovascular and neurological diseases and cancers.
期刊介绍:
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.