肠道微生物群在多囊卵巢综合征中的新作用

Yufeng He M.D. , Xing Jin Ph.D. , Haojue Wang M.D. , Hongyan Dai B.D. , Xianyi Lu B.D. , Jianxin Zhao Ph.D. , Hao Zhang M.D. , Wei Chen Ph.D. , Gang Wang Ph.D.
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引用次数: 2

摘要

多囊卵巢综合征(PCOS)是一种广泛影响育龄妇女的内分泌疾病。最近的研究表明肠道微生物群与多囊卵巢综合征之间存在密切联系。它们的微生物多样性可能不会发生显著变化,拟杆菌属在人类多囊卵巢综合征中的重要作用已得到证实。此外,PCOS动物模型表现出与PCOS患者不同的肠道微生物组特征。多囊卵巢综合征患者的肠道微生物群可能不同,因为它可能受到多种多囊卵巢综合征相关因素的影响。肠道菌群失调可能通过微生物代谢物(包括胆汁酸、短链脂肪酸和脂多糖)的潜在机制引发多囊卵巢综合征症状。肠道微生物组的控制可以影响PCOS的表型,益生元或益生菌治疗有可能改善PCOS的症状。未来的机制研究需要确定这些微生物及其代谢物在多囊卵巢综合征发病机制中的致病作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The emerging role of the gut microbiome in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder that affects women of reproductive age. Recent studies have demonstrated a close association between the gut microbiome and PCOS. Their microbial diversity may not significantly change, and the crucial role of Bacteroides spp. has been demonstrated in human PCOS. Furthermore, animal models of PCOS exhibit gut microbiome features different from those of humans with PCOS. The gut microbiome may differ in patients with PCOS because it can be affected by multiple PCOS-related factors. Dysbiosis of the gut microbiome may trigger PCOS symptoms via an underlying mechanism that may involve microbial metabolites, including bile acids, short-chain fatty acids, and lipopolysaccharides. The manipulation of the gut microbiome can affect PCOS phenotypes, and prebiotic or probiotic therapy has the potential to improve PCOS symptoms. Future mechanistic studies are required to identify the causative role of these microbes and their metabolites in the pathogenesis of PCOS.

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来源期刊
F&S reviews
F&S reviews Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Urology
CiteScore
3.70
自引率
0.00%
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0
审稿时长
61 days
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