直方图分析在磁共振弥散加权成像鉴别肾肿瘤亚群中的应用

IF 0.2 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Iranian Journal of Radiology Pub Date : 2021-10-11 DOI:10.5812/iranjradiol.110963

G. Erbay, M. Goren, E. Karadeli, B. Pekoz, Z. Koc, S. Arıca

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引用次数: 0

摘要

背景：肾肿瘤的组织病理学分化可能通过影像学具有挑战性。目的：评估表观扩散系数（ADC）图上直方图参数的差异，并研究直方图分析在区分嗜酸细胞瘤和恶性肾肿瘤（MRN）亚组中的疗效。患者和方法：在这项横断面回顾性研究中，对65例肾肿瘤患者（9例嗜酸细胞瘤和59例MRN）的弥散加权磁共振成像（DW-MRI）的纹理参数进行了评估，以进行组织学分析。结果：本研究共检查了来自50名男性和15名女性患者的68个病变，中位年龄为55.4岁。嗜酸细胞瘤和MRN亚组的ADC平均值、中值和峰值以及ADC百分位数存在显著差异。关于病变的组织病理学特征，9例（11.5%）嗜酸细胞瘤，23例（29.5%）透明细胞肾癌（ccRCC），14例（17.9%）乳头状肾癌（pRCC），12例（15.4%）嫌色肾细胞癌（chRCC），其他肿瘤10例（12.8%）（包括4例移行细胞癌、4例非霍奇金淋巴瘤和2例原始神经外胚层肿瘤）。嗜酸细胞瘤、pRCC、chRCC和其他MRN亚组的ADC平均值和中值存在显著差异。此外，ccRCC、pRCC和chRCC亚组的ADC平均值和中值存在显著差异。嗜酸细胞瘤与pRCC、chRCC和其他MRN亚组的平均ADC和中值ADC的百分位数也存在显著差异。然而，嗜酸细胞瘤组和ccRCC组的平均ADC和中值ADC（包括百分位直方图分析）或峰值ADC没有显著差异。肾肿块ADC的平均值、中位数和百分位数优于峰度、偏度和熵。结论：尽管仅通过测量ADC的平均值、中值和峰值不可能区分ccRCC和嗜酸细胞瘤，但ADC的直方图分析可能会改善MRN亚组之间的分化。显然，ADC不能用于区分嗜酸细胞瘤和MRNs。

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Use of Histogram Analysis in Diffusion-Weighted Magnetic Resonance Imaging for Differentiation of Renal Tumor Subgroups

Background: The histopathological differentiation of renal neoplasms can be challenging via imaging. Objectives: To evaluate differences in histogram parameters on apparent diffusion coefficient (ADC) maps and to investigate the efficacy of histogram analysis in differentiation of oncocytomas from malignant renal neoplasm (MRN) subgroups. Patients and Methods: In this cross-sectional, retrospective study, the texture parameters of diffusion-weighted magnetic resonance images (DW-MRI) were evaluated in 65 patients with renal tumors (nine cases of oncocytoma and 59 cases of MRN) for a histological analysis. Results: A total of 68 lesions from 50 male and 15 female patients, with a median age of 55.4 years, were examined in this study. There were significant differences in the mean, median, and peak ADC values, as well as ADC percentiles, between the oncocytoma and MRN subgroups. Regarding the histopathological features of the lesions, 9 (11.5%) cases of oncocytomas, 23 (29.5%) cases of clear cell renal carcinoma (ccRCC), 14 (17.9%) cases of papillary renal cell carcinoma (pRCC), 12 (15.4%) cases of chromophobe renal cell carcinoma (chRCC), and 10 (12.8%) other tumors (including four cases of transitional cell carcinoma, four cases of non-Hodgkin’s lymphoma, and two cases of primitive neuroectodermal tumor) were identified. Significant differences were found in the mean and median ADC values between the oncocytoma, pRCC, chRCC, and other MRN subgroups. Moreover, significant differences were found in the mean and median ADC values between the ccRCC, pRCC, and chRCC subgroups. There were also significant differences in the percentiles of mean and median ADCs between oncocytomas and pRCC, chRCC, and other MRN subgroups. However, there were no significant differences in the mean and median ADCs (including the percentile histogram analysis) or the peak ADC between the oncocytoma and ccRCC groups. The mean, median, and percentile of ADC for renal masses were superior to kurtosis, skewness, and entropy. Conclusion: Although differentiation between ccRCC and oncocytoma was not possible by only measuring the mean, median, and peak ADC values, the histogram analysis of ADCs may improve differentiation between the MRN subgroups. Clearly, ADC cannot be used to differentiate between oncocytomas and MRNs.

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来源期刊

Iranian Journal of Radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Iranian Journal of Radiology is the official journal of Tehran University of Medical Sciences and the Iranian Society of Radiology. It is a scientific forum dedicated primarily to the topics relevant to radiology and allied sciences of the developing countries, which have been neglected or have received little attention in the Western medical literature. This journal particularly welcomes manuscripts which deal with radiology and imaging from geographic regions wherein problems regarding economic, social, ethnic and cultural parameters affecting prevalence and course of the illness are taken into consideration. The Iranian Journal of Radiology has been launched in order to interchange information in the field of radiology and other related scientific spheres. In accordance with the objective of developing the scientific ability of the radiological population and other related scientific fields, this journal publishes research articles, evidence-based review articles, and case reports focused on regional tropics. Iranian Journal of Radiology operates in agreement with the below principles in compliance with continuous quality improvement: 1-Increasing the satisfaction of the readers, authors, staff, and co-workers. 2-Improving the scientific content and appearance of the journal. 3-Advancing the scientific validity of the journal both nationally and internationally. Such basics are accomplished only by aggregative effort and reciprocity of the radiological population and related sciences, authorities, and staff of the journal.