牙龈肉芽肿伴多血管炎:一例罕见的孤立表现。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Ashwin Parakkaje Subramanya, J. George, M. Prabhuji, R. Bavle, Sudhakara Muniswamappa
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引用次数: 1

摘要

肉芽肿伴多血管炎(GPA)是一种罕见的自身免疫性疾病,其特征是上下呼吸道坏死性肉芽肿性炎症、血管炎和肾小球肾炎。这种疾病可能表现为咳嗽、咯血、鼻窦炎、鼻腔畸形、皮肤病变、不适、发烧、厌食和体重减轻。口腔表现包括草莓牙龈炎,这是一种典型的临床表现。在这里,我们介绍了一例牙龈GPA的第一表现。口腔临床检查显示,下前牙区域有颗粒状、红斑性牙龈肿大,涉及乳头、边缘和附着的牙龈,表面有光泽和卵石。组织病理学检查显示假上皮瘤样增生伴血管炎,结缔组织炎症,中性粒细胞浸润和脓肿形成伴出血。实验室检测显示蛋白酶3(PR3)抗原和肾小球基底膜(GBM)抗原呈阳性。临床、组织病理学和实验室研究使肉芽肿伴多血管炎的诊断成为可能。我们报告了一例罕见的以牙龈为主要表现的GPA病例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Granulomatosis with polyangiitis in gingiva: A rare case of isolated presentation.
Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease characterized by necrotising granulomatous inflammation of upper and lower respiratory tract, vasculitis and glomerulonephritis. This ailment may present with cough, haemoptysis, sinusitis, nasal deformity, skin lesions, malaise, fever, anorexia, and weight loss. Oral manifestation includes strawberry gingivitis, which is a pathognomonic clinical presentation. Here, we present a case of GPA in gingiva as the first manifestation. Clinical examination of the oral cavity revealed granular, erythematous gingival enlargement in the lower anterior teeth region involving papilla, marginal and attached gingiva with shiny and pebbled surface. Histopathological examination showed pseudoepitheliomatous hyperplasia with vasculitis and inflammation in the connective tissue, neutrophilic infiltration and abscess formation with haemorrhage were noted. Laboratory investigations revealed Proteinase 3 (PR3) antigen and Glomerular basement membrane (GBM) antigen were positive. Clinical, histopathological and laboratory investigations enabled the diagnosis of Granulomatosis with Polyangiitis. We present this rare case report of GPA with primary manifestation in gingiva.
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来源期刊
Intractable & rare diseases research
Intractable & rare diseases research MEDICINE, GENERAL & INTERNAL-
CiteScore
2.10
自引率
0.00%
发文量
29
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