GABA能中间神经元在癫痫治疗中的应用进展

Journal of stem cell therapy and transplantation Pub Date : 2019-09-04 DOI:10.29328/journal.jsctt.1001014

Federica Frisina, G. Valetti, Giulia Zuccarini, L. Conti, G. Merlo

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引用次数: 1

摘要

缩写：5HT3aR：血清素受体3a；AED：抗癫痫药物；CB：钙结合蛋白；CGE：尾神经节卓越；中枢神经系统；CR：钙视网膜蛋白；DCX：双皮质素；胚胎干细胞；fEPSP:field兴奋性突触后电位；GABA：γ-氨基丁酸；胶质纤维酸性蛋白；HFO：高频振荡；IN：抑制神经元或神经元间；iPSC：诱导的多能干细胞；KA：Kainic Acid；外侧神经节隆起；MES：最大电击；MGE：正中神经节突出；NeuN：神经元核抗原；nNOS：神经元一氧化氮合酶；NPY：神经肽Y；神经干细胞；PTZ：戊四唑；PV：Parvalbumin；SE：癫痫状态；SRS：自发性复发性癫痫；SST：生长抑素；颞叶癫痫；VIP：血管活性肠肽简介

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Advances in the use of GABAergic interneurons for the treatment of epilepsy

Abbreviations: 5HT3aR: serotonin Receptor 3a; AED: Anti-Epileptic Drug; CB: Calbindin; CGE: Caudal Ganglionic Eminence; CNS: Central Nervous System; CR: Calretinin; DCX: Doublecortin; ESC: Embryonic Stem Cells; fEPSP: fi eld Excitatory Postsynaptic Potential; GABA: Gamma-AminoButirric Acid; GFAP: Glial Fibrillary Acidic Protein; HFO: High Frequency Oscillation; IN: Inhibitory Neurons or InterNeuron; iPSC: induced Pluripotent Stem Cells; KA: Kainic Acid; LGE: Lateral Ganglionic Eminence; MES: Maximal Electroshock; MGE: Median Ganglionic Eminence; NeuN: Neuronal Nuclear Antigen; nNOS: Neuronal Nitric Oxide Synthase; NPY: Neuropeptide Y; NSC: Neural Stem Cells; PTZ: Pentylenetetrazole; PV: Parvalbumin; SE: Status Epilepticus; SRS: Spontaneous Recurrent Seizures; SST: Somatostatin; TLE: Temporal Lobe Epilepsy; VIP: Vasoactive Intestinal Peptide Introduction

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Journal of stem cell therapy and transplantation

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