SARS-COV-2对常规治疗无反应所致分离性慢性无菌性脑膜炎

IF 0.5 Q4 PEDIATRICS

Archives of Pediatric Infectious Diseases Pub Date : 2021-02-14 DOI:10.5812/PEDINFECT.113175

A. Karimi, Sedigheh Rafiei Tabatabaei, G. Shariatpanahi, Mohsen Javadzadeh, S. Armin, Z. Yeganeh

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引用次数: 2

摘要

：由严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）引起的2019冠状病毒病（新冠肺炎）的严重并发症，有时甚至致命并发症是毁灭性的。尽管新冠肺炎的大多数表现是呼吸道疾病（发烧、干咳、疲劳、肺炎），但人们逐渐认识到，许多器官功能可能会受到这种疾病的影响，神经系统是其中之一，因为神经并发症可能影响高达36%的成年患者。然而，这些并发症在儿童中的发病率和病理生理学尚未完全阐明。在这里，我们讨论了一名患有神经系统症状的婴儿，该症状表现为与新冠肺炎相关的慢性孤立性无菌性脑膜炎，对普通治疗无反应，对地塞米松有显著反应。在这种情况下，免疫介导的反应可能具有重要的病理生理作用。

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Isolated Chronic Aseptic Meningitis Due to SARS-COV-2 Unresponsive to Ordinary Treatments

: Serious, and sometimes, deadly complications of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are devastating. Whereas most manifestations of COVID-19 are respiratory (fever, dry cough, fatigue, pneumonia), it is getting to be progressively recognized that numerous organ functions can be affected by this disease, and the nervous system is one of them as neurological complications can affect up to 36% of adult patients. However, the prevalence and pathophysiology of these complications have yet to be fully elucidated in children. Here, we discuss an infant with neurological symptoms manifested as chronic isolated aseptic meningitis associated with COVID-19, which was unresponsive to ordinary treatments and dramatically responsive to dexamethasone. Immune-mediated reactions may have had a major pathophysiologic role in this case.

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来源期刊

Archives of Pediatric Infectious Diseases PEDIATRICS-

CiteScore

1.80

自引率

14.30%

发文量

期刊介绍： Archives Of Pediatric Infectious Disease is a clinical journal which is informative to all practitioners like pediatric infectious disease specialists and internists. This authoritative clinical journal was founded by Professor Abdollah Karimi in 2012. The Journal context is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates and consensus statements of clinical relevance to pediatric disease field, especially infectious diseases. In addition, consensus evidential reports not only highlight the new observations, original research and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in the journal.