寻求命运- crispra筛选揭示新的神经谱系和重编程因素。

Q1 Biochemistry, Genetics and Molecular Biology

Stem cell investigation Pub Date : 2019-09-09 DOI:10.21037/sci.2019.08.03

Valentin Baumann, S. Stricker

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引用次数: 1

摘要

这仍然是生物学中最有趣的问题之一，一个生物体所拥有的多种细胞类型是如何在发育过程中充分产生的。很明显，有一些转录因子具有足够的活性来驱动细胞走向特定的细胞身份，但迄今为止，已知的基因仅限于少数谱系（如多能性、神经发生、β细胞发育等），即使在这些情况下，我们也远未全面了解促成因子和分子机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Seeking fate-CRISPRa screens reveal new neural lineage and reprogramming factors.

It is still one of the most intriguing questions in biology, how the multitudes of cell types a single organism possesses, are adequately born during development. It is clear that there are transcription factors with sufficient activity to drive cells towards specific cell identities, however to date the known genes are limited to a handful of linages (e.g., pluripotency, neurogenesis, β-cell development, etc.) and even in these cases we are far from a comprehensive understanding of contributing factors and molecular mechanisms.

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来源期刊

Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

5.80

自引率

0.00%

发文量

期刊介绍： The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.