在资源有限的环境中寻找更简单敏感的诊断方法来评估妊娠期疟疾流行率

C. A. Ihemanma, P. Melariri, W. Sibanda, P. Etusim
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引用次数: 0

摘要

背景:怀孕期间感染疟疾会导致产妇死亡,对胎儿和婴儿造成严重后果。本研究旨在通过尿液分析评估孕妇的患病率和临床症状。方法:一项横断面研究涉及从六个医疗保健中心选择的300名孕妇。结果:疟疾总患病率为48%(n=143)。≤25岁年龄组的患病率最高,为55.8%(n=68)。妊娠早期和中期的孕妇患病率分别为49%(n=101)和49%(n=77),而初产妇的患病率最高,为56%(n=91)。Logistic回归显示,30岁以下的女性疟疾阴性的几率较低,OR为0.96(95%CI为0.56-1.65),P=0.87。妊娠早期的女性疟疾阴性的几率更高,为1.01(95%CI 0.41-2.46),P=0.99。使用LLIN的女性疟疾阴性的几率更高,OR 4521746.902,P=0.0000。结论:尿液分析显示,胆红素尿(+)样本的患病率最高,为27.3%(n=82)。妊娠期胆红素尿可作为疟疾的良好指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Searching for simpler sensitive diagnostic methods for assessing malaria prevalence during pregnancy in resource constrained setting
Background: Malaria infection during pregnancy causes maternal mortality with severe consequences for the foetus and infant. This research was aimed at assessing prevalence and clinical symptoms via urinalysis among pregnant women.Method: A cross-sectional study involving 300 pregnant women purposively selected from six health care centres was conducted. Data were analysed  using SPSS version 26.Results: The overall malaria prevalence rate was 48% (n=143). Age group ≤25 years had the highest prevalence rate of 55.8% (n=68). Pregnant women in  their first and second trimester had prevalence rate of 49% (n=101) and 49% (n=77) respectively, while the primigravidae recorded the highest prevalence  rate of 56% (n=91). Logistic regression revealed that women younger than 30 years old had lower odds of being malaria negative OR 0.96(95%Cl  0.56-1.65), P=0.87. Women in their first trimester had higher odds of being malaria negative by 1.01 (95%Cl 0.41-2.46), P=0.99. Women who used LLINs had higher odds of being malaria negative OR 4521746.902, P=0.0000.Conclusion: Urinalysis revealed highest prevalence rate of 27.3% (n=82) for bilirubinuria (+) samples. Bilirubinuria in pregnancy could serve as a good  indicator for malaria.
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