血浆珠蛋白和群体特异性成分表型变异增加慢性肾脏疾病的风险

Pub Date : 2022-02-10 DOI:10.31901/24566330.2022/22.01.800

Pavani Sanapala

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引用次数: 0

摘要

摘要研究人员使用不连续聚丙烯酰胺凝胶电泳研究了慢性肾脏病（CKD）患者和非CKD对照组中触珠蛋白（HP）和组特异性成分（GC）血浆蛋白生物标志物的相关性。结果显示，CKD与HP（p=0.0036）和GC（p=0.0033）的2-2变异体对照组之间存在显著差异。目前的研究表明，2-2表型是CKD的独立风险决定因素，而风险分析报告，两种蛋白质多态性的比值值均>1，这意味着CKD的有效风险。多因素降维分析还详细说明了HP和GC标记物具有更强的相关性，是CKD发展的原因。总之，这些发现表明血浆HP和GC多态性易患CKD的潜在风险及其在肾功能恶化中的关键作用。

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Plasma Haptoglobin and Group-specific Component Phenotypic Variants Increase the Risk of Chronic Kidney Disease

ABSTRACT The researchers studied the correlation of Haptoglobin (HP) and Group-specific Component (GC) plasma protein biomarkers in chronic kidney disease (CKD) patients and non-CKD controls using discontinuous-polyacrylamide gel electrophoresis. The results showed a significant difference between the CKD and control clusters of 2-2 variants for HP (p=0.0036) and GC (p= 0.0033). The current research indicates 2-2 phenotype is an independent risk determinant for CKD, while risk analysis reports odds value >1 for both protein polymorphisms signifying an effective risk towards CKD. The multifactor dimensional reduction analysis also detailed HP and GC markers have a strengthening and stronger association and are causative for CKD development. Collectively, the findings signify a potential risk of plasma HP and GC polymorphisms being susceptible to CKD and their key role in the deterioration of kidney functions.

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