{"title":"防晒抗氧化活性化合物3,3′-二羟基-4,4′-二甲氧基二苄基丙酮的合成及初步评价","authors":"Harizal Harizal, Ariyo Prabowo Hidayanto, N. Sari","doi":"10.30872/jkm.v16i1.665","DOIUrl":null,"url":null,"abstract":"Synthesis and preliminary evaluation of 3,3’-dihydroxy-4,4’-dimethoxydibenzylidenacetone (DDB) as sunscreen and antioxidant have been successfully conducted. The compound was prepared throught acid catalyzed condensation reaction between vanillin and aceton using saturated HCl solution in glacial acetic acid. Pre-evaluation of sunscreen active compound candidate was performed by determining electronic absorbance profile, lamdamax, e, lamda c, UVA/UVB ratio, and photostability. While antioxidant activity test was performed using DPPH radical scavenger method. Based on the results obtained, the compound obtained has very good protective effect in UVA regions with high antioxidant activity.","PeriodicalId":31725,"journal":{"name":"Jurnal Kimia Mulawarman","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"SYNTHESIS AND PRELIMINARY EVALUATION OF 3,3’-DIHYDROXY-4,4’-DIMETHOXYDIBENZYLIDENEACETONE AS SUNSCREEN AND ANTIOXIDANT ACTIVE COMPOUND\",\"authors\":\"Harizal Harizal, Ariyo Prabowo Hidayanto, N. Sari\",\"doi\":\"10.30872/jkm.v16i1.665\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Synthesis and preliminary evaluation of 3,3’-dihydroxy-4,4’-dimethoxydibenzylidenacetone (DDB) as sunscreen and antioxidant have been successfully conducted. The compound was prepared throught acid catalyzed condensation reaction between vanillin and aceton using saturated HCl solution in glacial acetic acid. Pre-evaluation of sunscreen active compound candidate was performed by determining electronic absorbance profile, lamdamax, e, lamda c, UVA/UVB ratio, and photostability. While antioxidant activity test was performed using DPPH radical scavenger method. Based on the results obtained, the compound obtained has very good protective effect in UVA regions with high antioxidant activity.\",\"PeriodicalId\":31725,\"journal\":{\"name\":\"Jurnal Kimia Mulawarman\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jurnal Kimia Mulawarman\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30872/jkm.v16i1.665\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jurnal Kimia Mulawarman","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30872/jkm.v16i1.665","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SYNTHESIS AND PRELIMINARY EVALUATION OF 3,3’-DIHYDROXY-4,4’-DIMETHOXYDIBENZYLIDENEACETONE AS SUNSCREEN AND ANTIOXIDANT ACTIVE COMPOUND
Synthesis and preliminary evaluation of 3,3’-dihydroxy-4,4’-dimethoxydibenzylidenacetone (DDB) as sunscreen and antioxidant have been successfully conducted. The compound was prepared throught acid catalyzed condensation reaction between vanillin and aceton using saturated HCl solution in glacial acetic acid. Pre-evaluation of sunscreen active compound candidate was performed by determining electronic absorbance profile, lamdamax, e, lamda c, UVA/UVB ratio, and photostability. While antioxidant activity test was performed using DPPH radical scavenger method. Based on the results obtained, the compound obtained has very good protective effect in UVA regions with high antioxidant activity.
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