微波消解法研究不同剂型布洛芬的ICP-OES元素杂质

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-05-11 DOI:10.20450/MJCCE.2021.2100

Katerina Jancevska, G. Petrushevski, Mirjana Bogdanoska, T. Stafilov, S. Ugarkovic

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引用次数: 2

摘要

开发了快速简单的封闭容器微波辅助消化程序，用于分解布洛芬的三种药物剂型，如片剂、悬浮液和凝胶，然后通过一种稳健精确的ICP-OES方法进行元素杂质分析。通过四步微波程序消化样品，包括10分钟的温度梯度至180°C，在180°C下保持10分钟，然后在210°C上保持10分钟的升温时间至210°C。随后，开发并验证了ICP-OES方法，用于同时测定选定的元素杂质。所有分析配方中每种元素的回收率研究结果在77%至105%之间。所有分析元素的回归方程的相关系数均高于0.999。验证结果表明，该方法具有特异性、准确性和精密性，可用于布洛芬不同剂型中多元素溶液的同时定量分析。

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ICP-OES elemental impurities study on different pharmaceutical dosage forms of Ibuprofen using microwave-assisted digestion procedure

Fast and simple closed-vessel microwave-assisted digestion procedure was developed for decomposition of three pharmaceutical dosage forms of ibuprofen such as tablets, suspension and gel, prior to elemental impurity analysis by one robust and precise ICP-OES method. Samples were digested by four-step microwave program consisting of a 10 min temperature gradient to 180°C, maintained at 180°C for 10 min, followed by 5 min ramping time to 210°C with holding time of 10 min on 210°C. Subsequently, ICP-OES method was developed and validated for simultaneous determination of selected elemental impurities. Results of recovery studies range between 77% and 105% for each element in all analyzed formulations. Correlation coefficients of the regression equations were higher than 0.999 for all analyzed elements. Validation results reveal that the proposed method is specific, accurate, and precise and could be applied for simultaneous quantitative analysis of multi element solutions in different pharmaceutical dosage forms of ibuprofen.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.