B. Gautam, K. Sherpa, R. Poudel, P. Shrestha, D. Sharma, R. Sah, R. Malla, A. Maskey, M. K.C, S. Rajbhandari
{"title":"三级护理中心接受冠状动脉搭桥术的患者颈动脉内膜-中膜厚度与冠状动脉疾病严重程度的关系","authors":"B. Gautam, K. Sherpa, R. Poudel, P. Shrestha, D. Sharma, R. Sah, R. Malla, A. Maskey, M. K.C, S. Rajbhandari","doi":"10.3126/njh.v16i2.26315","DOIUrl":null,"url":null,"abstract":"Background and Aims: Atherosclerosis is an inflammatory process involving arteries in various organs. Carotid intima medial thickness (CIMT) can be useful noninvasive tool to detect atherosclerosis for diagnosis of significant cardiovascular disease. We aim to study the association of CIMT with severity of Coronary Artery Disease (CAD). \nMethods: This was a cross sectional, observational study conducted in 81 patients with mean age of 59.9± 8.5 years with a diagnosis of CAD undergoing coronary artery bypass graft (CABG) surgery. The CIMT was measured with B-mode ultrasound in all patients and association with severity of CAD was measured. \nResults: The prevalence of increased CIMT in our study group was 31% and carotid plaque was 69%. Presence of carotid plaque was significantly associated with severe grade CAD stenosis (t = 4, p < 0.001) and presence of Chronic Total Occlusion (CTO) (p = 0.028). There was no significant correlation between mean CIMT and severity of CAD expressed as mean percentage stenosis (r = 0.179, p = 0.11) but patients with CTO had higher mean CIMT value than non-CTO group (0.86 ± 0.21 Vs 0.73 ± 0.18; p = 0.027). We found that diabetic population had greater mean CIMT values than nondiabetic population (0.82 ± 0.21 Vs 0.72 ± 0.17; p = 0.017) and higher prevalence of carotid plaque (p = 0.02). Similarly, females were more likely to have increased CIMT than males (p=0.004). \nConclusion: We found that increased CIMT was associated with presence of CTO. Presence of carotid plaque was associated with severe grading of CAD and CTO. Carotid ultrasound can be useful noninvasive modality to predict presence of significant CAD.","PeriodicalId":52010,"journal":{"name":"Nepalese Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.1000,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/njh.v16i2.26315","citationCount":"1","resultStr":"{\"title\":\"Association of Carotid Intima Media Thickness with the severity of Coronary Artery Disease in patients undergoing Coronary Artery Bypass Graft Surgery in a tertiary care center\",\"authors\":\"B. Gautam, K. Sherpa, R. Poudel, P. Shrestha, D. Sharma, R. Sah, R. Malla, A. Maskey, M. K.C, S. Rajbhandari\",\"doi\":\"10.3126/njh.v16i2.26315\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background and Aims: Atherosclerosis is an inflammatory process involving arteries in various organs. Carotid intima medial thickness (CIMT) can be useful noninvasive tool to detect atherosclerosis for diagnosis of significant cardiovascular disease. We aim to study the association of CIMT with severity of Coronary Artery Disease (CAD). \\nMethods: This was a cross sectional, observational study conducted in 81 patients with mean age of 59.9± 8.5 years with a diagnosis of CAD undergoing coronary artery bypass graft (CABG) surgery. The CIMT was measured with B-mode ultrasound in all patients and association with severity of CAD was measured. \\nResults: The prevalence of increased CIMT in our study group was 31% and carotid plaque was 69%. Presence of carotid plaque was significantly associated with severe grade CAD stenosis (t = 4, p < 0.001) and presence of Chronic Total Occlusion (CTO) (p = 0.028). There was no significant correlation between mean CIMT and severity of CAD expressed as mean percentage stenosis (r = 0.179, p = 0.11) but patients with CTO had higher mean CIMT value than non-CTO group (0.86 ± 0.21 Vs 0.73 ± 0.18; p = 0.027). We found that diabetic population had greater mean CIMT values than nondiabetic population (0.82 ± 0.21 Vs 0.72 ± 0.17; p = 0.017) and higher prevalence of carotid plaque (p = 0.02). Similarly, females were more likely to have increased CIMT than males (p=0.004). \\nConclusion: We found that increased CIMT was associated with presence of CTO. Presence of carotid plaque was associated with severe grading of CAD and CTO. 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引用次数: 1
摘要
背景和目的:动脉粥样硬化是一种累及各器官动脉的炎症过程。颈动脉内膜中层厚度(CIMT)是一种有用的无创检测动脉粥样硬化的工具,可用于诊断重大心血管疾病。我们的目的是研究CIMT与冠状动脉疾病(CAD)严重程度的关系。方法:这是一项横断面观察性研究,对81例平均年龄59.9±8.5岁的冠心病患者进行了冠状动脉旁路移植术(CABG)。所有患者均采用b超测量CIMT,并测量其与冠心病严重程度的相关性。结果:我们研究组中CIMT升高的发生率为31%,颈动脉斑块发生率为69%。颈动脉斑块的存在与严重级别CAD狭窄(t = 4, p < 0.001)和慢性全闭塞(CTO)的存在显著相关(p = 0.028)。平均CIMT与以平均狭窄百分比表示的CAD严重程度之间无显著相关性(r = 0.179, p = 0.11),但CTO患者的平均CIMT值高于非CTO组(0.86±0.21 Vs 0.73±0.18;P = 0.027)。我们发现糖尿病人群的平均CIMT值高于非糖尿病人群(0.82±0.21 Vs 0.72±0.17;P = 0.017),颈动脉斑块患病率较高(P = 0.02)。同样,女性比男性更有可能增加CIMT (p=0.004)。结论:我们发现CIMT的增加与CTO的存在有关。颈动脉斑块的存在与CAD和CTO的严重分级有关。颈动脉超声是一种有用的非侵入性方法,可以预测是否存在显著的CAD。
Association of Carotid Intima Media Thickness with the severity of Coronary Artery Disease in patients undergoing Coronary Artery Bypass Graft Surgery in a tertiary care center
Background and Aims: Atherosclerosis is an inflammatory process involving arteries in various organs. Carotid intima medial thickness (CIMT) can be useful noninvasive tool to detect atherosclerosis for diagnosis of significant cardiovascular disease. We aim to study the association of CIMT with severity of Coronary Artery Disease (CAD).
Methods: This was a cross sectional, observational study conducted in 81 patients with mean age of 59.9± 8.5 years with a diagnosis of CAD undergoing coronary artery bypass graft (CABG) surgery. The CIMT was measured with B-mode ultrasound in all patients and association with severity of CAD was measured.
Results: The prevalence of increased CIMT in our study group was 31% and carotid plaque was 69%. Presence of carotid plaque was significantly associated with severe grade CAD stenosis (t = 4, p < 0.001) and presence of Chronic Total Occlusion (CTO) (p = 0.028). There was no significant correlation between mean CIMT and severity of CAD expressed as mean percentage stenosis (r = 0.179, p = 0.11) but patients with CTO had higher mean CIMT value than non-CTO group (0.86 ± 0.21 Vs 0.73 ± 0.18; p = 0.027). We found that diabetic population had greater mean CIMT values than nondiabetic population (0.82 ± 0.21 Vs 0.72 ± 0.17; p = 0.017) and higher prevalence of carotid plaque (p = 0.02). Similarly, females were more likely to have increased CIMT than males (p=0.004).
Conclusion: We found that increased CIMT was associated with presence of CTO. Presence of carotid plaque was associated with severe grading of CAD and CTO. Carotid ultrasound can be useful noninvasive modality to predict presence of significant CAD.