中国汉族丙型肝炎患者代谢综合征的患病率及危险因素

中华传染病杂志 Pub Date : 2018-10-15 DOI:10.3760/CMA.J.ISSN.1000-6680.2018.10.005

Ying-hui Gao, H. Rao, Rui‐feng Yang, J. Shang, Hong Chen, Jun Li, Q. Xie, Zhiliang Gao, Lei Wang, Jia Wei, Jianning Jiang, Yongtao Sun, R. Fei, Haiying Zhang, X. Kong, Q. Jin, Jian Wang

{"title":"中国汉族丙型肝炎患者代谢综合征的患病率及危险因素","authors":"Ying-hui Gao, H. Rao, Rui‐feng Yang, J. Shang, Hong Chen, Jun Li, Q. Xie, Zhiliang Gao, Lei Wang, Jia Wei, Jianning Jiang, Yongtao Sun, R. Fei, Haiying Zhang, X. Kong, Q. Jin, Jian Wang","doi":"10.3760/CMA.J.ISSN.1000-6680.2018.10.005","DOIUrl":null,"url":null,"abstract":"Objective \nTo evaluate the prevalence and risk factors of metabolic syndrome among hepatitis C patients in Chinese Han population. \n \n \nMethods \nThis was a multicenter, cross-sectional study. A total of 997 Chinese Han patients with hepatitis C virus (HCV) infection were enrolled. Demographic data, anthropometric data and clinical parameters related to metabolic syndrome were collected. Statistical analysis was performed by t-test (normal distribution) or Mann-Whitney U two-sample test (non-normal distribution) and χ2 test. Binary logistic regression analyses were used to determine the parameters significantly related to metabolic syndrome. \n \n \nResults \nAmong the 997 patients, 170 (17.1%) patients were diagnosed with metabolic syndrome. Binary logistic regression showed that genotype 2 (OR=1.594; 95%CI: 1.045-2.431, P=0.030), older age (OR=1.040; 95%CI: 1.022-1.058, P<0.01), overweight (OR=3.876; 95%CI: 2.593-5.792, P<0.01), fatty liver history (OR=2.106; 95%CI: 1.384-3.204, P=0.001), homeostasis model assessment insulin (HOMA-IR) (OR=1.263; 95%CI: 1.118-1.427, P<0.01), fasting insulin (OR=0.949; 95%CI: 0.915-0.985, P=0.006), lower serum albumin level (OR=0.957; 95%CI: 0.915-1.000, P=0.049) and higher γ-GT level (OR=1.004; 95%CI: 1.000-1.008, P=0.0041) were all significantly associated with the presence of metabolic syndrome. \n \n \nConclusions \nHepatitis C patients with genotype 2, older age, overweight, fatty liver history, higher HOMA-IR, lower fasting insulin level, lower serum albumin level or higher γ-GT level should be screened for metabolic syndrome. \n \n \nKey words: \nHepatitis C chronic; Genotype; Metabolic syndrome","PeriodicalId":10127,"journal":{"name":"中华传染病杂志","volume":"36 1","pages":"599-604"},"PeriodicalIF":0.0000,"publicationDate":"2018-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The prevalence and risk factors of metabolic syndrome among hepatitis C patients in Chinese Han population\",\"authors\":\"Ying-hui Gao, H. Rao, Rui‐feng Yang, J. Shang, Hong Chen, Jun Li, Q. Xie, Zhiliang Gao, Lei Wang, Jia Wei, Jianning Jiang, Yongtao Sun, R. Fei, Haiying Zhang, X. Kong, Q. Jin, Jian Wang\",\"doi\":\"10.3760/CMA.J.ISSN.1000-6680.2018.10.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo evaluate the prevalence and risk factors of metabolic syndrome among hepatitis C patients in Chinese Han population. \\n \\n \\nMethods \\nThis was a multicenter, cross-sectional study. A total of 997 Chinese Han patients with hepatitis C virus (HCV) infection were enrolled. Demographic data, anthropometric data and clinical parameters related to metabolic syndrome were collected. Statistical analysis was performed by t-test (normal distribution) or Mann-Whitney U two-sample test (non-normal distribution) and χ2 test. Binary logistic regression analyses were used to determine the parameters significantly related to metabolic syndrome. \\n \\n \\nResults \\nAmong the 997 patients, 170 (17.1%) patients were diagnosed with metabolic syndrome. Binary logistic regression showed that genotype 2 (OR=1.594; 95%CI: 1.045-2.431, P=0.030), older age (OR=1.040; 95%CI: 1.022-1.058, P<0.01), overweight (OR=3.876; 95%CI: 2.593-5.792, P<0.01), fatty liver history (OR=2.106; 95%CI: 1.384-3.204, P=0.001), homeostasis model assessment insulin (HOMA-IR) (OR=1.263; 95%CI: 1.118-1.427, P<0.01), fasting insulin (OR=0.949; 95%CI: 0.915-0.985, P=0.006), lower serum albumin level (OR=0.957; 95%CI: 0.915-1.000, P=0.049) and higher γ-GT level (OR=1.004; 95%CI: 1.000-1.008, P=0.0041) were all significantly associated with the presence of metabolic syndrome. \\n \\n \\nConclusions \\nHepatitis C patients with genotype 2, older age, overweight, fatty liver history, higher HOMA-IR, lower fasting insulin level, lower serum albumin level or higher γ-GT level should be screened for metabolic syndrome. \\n \\n \\nKey words: \\nHepatitis C chronic; Genotype; Metabolic syndrome\",\"PeriodicalId\":10127,\"journal\":{\"name\":\"中华传染病杂志\",\"volume\":\"36 1\",\"pages\":\"599-604\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华传染病杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1000-6680.2018.10.005\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华传染病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1000-6680.2018.10.005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

目的了解中国汉族丙型肝炎患者代谢综合征的患病率及危险因素。方法这是一项多中心、横断面研究。共有997名中国汉族丙型肝炎病毒（HCV）感染者被纳入研究。收集与代谢综合征相关的人口统计学数据、人体测量数据和临床参数。统计分析采用t检验（正态分布）或Mann-Whitney U双样本检验（非正态分布，χ2检验）。二元逻辑回归分析用于确定与代谢综合征显著相关的参数。结果997例患者中，170例（17.1%）被诊断为代谢综合征。二元逻辑回归显示，基因型2（OR=1.594；95%CI:1.045-2.431，P=0.030）、年龄较大（OR=1.040；95%CI:10.022-1.058，P<0.01）、超重（OR=3.876；95%CI:2.593-5.792，P<0.01），脂肪肝病史（OR=2.106；95%CI:1.384-3.204，P=0.001）、稳态模型评估胰岛素（HOMA-IR）（OR=1.263；95%CI:1.118-1.427，P<0.01），较低的血清白蛋白水平（OR=0.957；95%CI:0.915-1000，P=0.049）和较高的γ-GT水平（OR=1.004；95%CI:1.00-1.008，P=0.0041）均与代谢综合征的存在显著相关。结论2型、年龄较大、超重、有脂肪肝病史、HOMA-IR较高、空腹胰岛素水平较低、血清白蛋白水平较低或γ-GT水平较高的丙型肝炎患者应进行代谢综合征筛查。关键词：丙型肝炎慢性；基因型；代谢综合征

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The prevalence and risk factors of metabolic syndrome among hepatitis C patients in Chinese Han population

Objective To evaluate the prevalence and risk factors of metabolic syndrome among hepatitis C patients in Chinese Han population. Methods This was a multicenter, cross-sectional study. A total of 997 Chinese Han patients with hepatitis C virus (HCV) infection were enrolled. Demographic data, anthropometric data and clinical parameters related to metabolic syndrome were collected. Statistical analysis was performed by t-test (normal distribution) or Mann-Whitney U two-sample test (non-normal distribution) and χ2 test. Binary logistic regression analyses were used to determine the parameters significantly related to metabolic syndrome. Results Among the 997 patients, 170 (17.1%) patients were diagnosed with metabolic syndrome. Binary logistic regression showed that genotype 2 (OR=1.594; 95%CI: 1.045-2.431, P=0.030), older age (OR=1.040; 95%CI: 1.022-1.058, P<0.01), overweight (OR=3.876; 95%CI: 2.593-5.792, P<0.01), fatty liver history (OR=2.106; 95%CI: 1.384-3.204, P=0.001), homeostasis model assessment insulin (HOMA-IR) (OR=1.263; 95%CI: 1.118-1.427, P<0.01), fasting insulin (OR=0.949; 95%CI: 0.915-0.985, P=0.006), lower serum albumin level (OR=0.957; 95%CI: 0.915-1.000, P=0.049) and higher γ-GT level (OR=1.004; 95%CI: 1.000-1.008, P=0.0041) were all significantly associated with the presence of metabolic syndrome. Conclusions Hepatitis C patients with genotype 2, older age, overweight, fatty liver history, higher HOMA-IR, lower fasting insulin level, lower serum albumin level or higher γ-GT level should be screened for metabolic syndrome. Key words: Hepatitis C chronic; Genotype; Metabolic syndrome

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华传染病杂志

自引率

0.00%

发文量

5280

期刊介绍： The Chinese Journal of Infectious Diseases was founded in February 1983. It is an academic journal on infectious diseases supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by the Shanghai Medical Association. The journal targets infectious disease physicians as its main readers, taking into account physicians of other interdisciplinary disciplines, and timely reports on leading scientific research results and clinical diagnosis and treatment experience in the field of infectious diseases, as well as basic theoretical research that has a guiding role in the clinical practice of infectious diseases and is closely integrated with the actual clinical practice of infectious diseases. Columns include reviews (including editor-in-chief reviews), expert lectures, consensus and guidelines (including interpretations), monographs, short monographs, academic debates, epidemic news, international dynamics, case reports, reviews, lectures, meeting minutes, etc.