2型糖尿病患者血清肝酶与甲状腺激素和内脏脂肪指数的相关性

Q4 Medicine

中华内分泌代谢杂志 Pub Date : 2020-04-25 DOI:10.3760/CMA.J.CN311282-20191025-00447

Mi-la Jia, Bo Feng

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引用次数: 0

摘要

目的探讨2型糖尿病（T2DM）患者血清肝酶与甲状腺激素和内脏脂肪指数（CVAI）的关系，探讨肝酶的影响因素。方法将700例2型糖尿病患者分为肝酶升高组和肝酶正常组，或按丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和谷氨酰转移酶（GGT）的三分位数分为三组。比较各组甲状腺激素和CVAI的差异，并测定肝酶水平与甲状腺激素和CV AI的相关性。结果与正常肝酶组相比，肝酶升高组甲状腺素（T4）和CVAI均升高（P＜0.05），游离三碘甲状腺（FT3）、T3和T4水平随ALT和AST升高而升高（P＞0.05），T4与ALT、AST呈正相关。ALT、GGT与CVAI呈正相关。CVAI与FT3、T3呈正相关。HbA1C与FT3、T4和T3呈负相关。回归分析表明，FT3、CVAI和HbA1C是ALT的影响因素，T4是AST的影响因素；T3和HbA1C是GGT的影响因素。结论T2DM患者甲状腺激素和CVAI与肝酶活性有关。关键词：糖尿病，2型；丙氨酸氨基转移酶；天冬氨酸转氨酶；谷氨酰转移酶；甲状腺激素；中国人内脏脂肪指数

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Association of serum liver enzymes with thyroid hormones and Chinese visceral adipose index in patients with type 2 diabetes mellitus

Objective To explore the association of serum liver enzymes with thyroid hormones and Chinese visceral adipose index (CVAI) in patients with type 2 diabetes mellitus (T2DM), and to evaluate the influencing factors of liver enzymes. Methods A total of 700 patients with T2DM were divided into elevated liver enzyme group and normal liver enzyme group, or three groups according to tertiles in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutamyltransferase (GGT). The differences of thyroid hormones and CVAI among groups were compared, and the correlations of liver enzyme levels with thyroid hormones and CVAI were determined. Results Compared with the normal liver enzyme group, thyroxine(T4)and CVAI were increased in the elevated liver enzyme group (P<0.05). Free triiodothyroid (FT3), triiodothyroid (T3), and T4 levels were elevated with the increase of ALT and AST (P<0.05). CVAI was elevated with the increase of ALT and GGT (P<0.05). Correlation analysis showed that FT3, T3, and T4were positively correlated with ALT and AST. ALT and GGT were positively correlated with CVAI. CVAI was positively correlated with FT3 and T3. HbA1Cwas negatively correlated with FT3, T4, and T3. Regression analysis showed that FT3, CVAI, and HbA1C were the influencing factors for ALT, T4 was the influencing factor for AST, T3 and HbA1Cwere the influencing factors for GGT. Conclusions In patients with T2DM, thyroid hormones and CVAI are correlated with liver enzymes. Key words: Diabetes mellitus, type 2; Alanine aminotransferase; Aspartate aminotransferase; Glutamyltransferase; Thyroid hormones; Chinese visceral adipose index

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来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.