A. Balogun, J. Taiwo, O. Opeodu, Bukola Folashade Adeyemi, B. Kolude
{"title":"非手术牙周治疗对慢性牙周炎患者唾液组织金属蛋白酶-1 (TIMP-1)水平的影响:第三世界经验","authors":"A. Balogun, J. Taiwo, O. Opeodu, Bukola Folashade Adeyemi, B. Kolude","doi":"10.4236/OJST.2021.115017","DOIUrl":null,"url":null,"abstract":"Chronic periodontitis is a disease of public health concern due to its high prevalence globally, especially in the elderly. The aim of this study was to determine the impact of non-surgical periodontal therapy on salivary levels of TIMP-1 among patients with chronic periodontitis in Nigeria. In this experimental study, unstimulated whole saliva (2 mL) was collected from participants in the experimental and control groups, coded (SP1-40 and SH1-40) respectively and assays for salivary TIMP-1as well as clinical measurements such as plaque (PI), probing depths (PD), and CAL were recorded before and 4 weeks after periodontal treatment. Assay was done using Quantikine human TIMP-1 ELISA kit. Data were presented using frequency tables, means and standard deviation. Paired-T Test assessed association between salivary TIMP-1 before and after treatment. Pearson correlation coefficient was used to correlate salivary TIMP-1 levels with clinical parameters of periodontal disease and levels of statistical significance were set at p < 0.05. A total of 80 respondents participated in the study of which 43.80% were females. Age range was 18 - 60 years with a mean of 35.8 ± 12.46 years. Salivary TIMP-1 levels were lower in the case group (13.58 ± 6.53 ng/mL) than the control (15.27 ± 6.10 ng/mL) at baseline but this was not statistically significant (p = 0.13). There was a statistically significant increase in the salivary levels of TIMP-1 in the case group after phase-one periodontal therapy from 13.58 ± 6.53 ng/mL to 17.24 ± 8.44 ng/mL (p = 0.001). Negative correlations were observed between TIMP-1 and clinical parameters of periodontitis. This was not statistically significant. Therefore, TIMP-1 may not be an ideal biomarker for periodontal diagnosis but may be useful in treatment monitoring of the disease.","PeriodicalId":56569,"journal":{"name":"口腔学期刊(英文)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Impact of Non-Surgical Periodontal Therapy on the Salivary Levels of Tissue Inhibitor of Metalloproteinse-1 (TIMP-1) in Patients with Chronic Periodontitis: A Third World Experience\",\"authors\":\"A. Balogun, J. Taiwo, O. Opeodu, Bukola Folashade Adeyemi, B. Kolude\",\"doi\":\"10.4236/OJST.2021.115017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Chronic periodontitis is a disease of public health concern due to its high prevalence globally, especially in the elderly. The aim of this study was to determine the impact of non-surgical periodontal therapy on salivary levels of TIMP-1 among patients with chronic periodontitis in Nigeria. In this experimental study, unstimulated whole saliva (2 mL) was collected from participants in the experimental and control groups, coded (SP1-40 and SH1-40) respectively and assays for salivary TIMP-1as well as clinical measurements such as plaque (PI), probing depths (PD), and CAL were recorded before and 4 weeks after periodontal treatment. Assay was done using Quantikine human TIMP-1 ELISA kit. Data were presented using frequency tables, means and standard deviation. Paired-T Test assessed association between salivary TIMP-1 before and after treatment. Pearson correlation coefficient was used to correlate salivary TIMP-1 levels with clinical parameters of periodontal disease and levels of statistical significance were set at p < 0.05. A total of 80 respondents participated in the study of which 43.80% were females. Age range was 18 - 60 years with a mean of 35.8 ± 12.46 years. Salivary TIMP-1 levels were lower in the case group (13.58 ± 6.53 ng/mL) than the control (15.27 ± 6.10 ng/mL) at baseline but this was not statistically significant (p = 0.13). There was a statistically significant increase in the salivary levels of TIMP-1 in the case group after phase-one periodontal therapy from 13.58 ± 6.53 ng/mL to 17.24 ± 8.44 ng/mL (p = 0.001). Negative correlations were observed between TIMP-1 and clinical parameters of periodontitis. This was not statistically significant. Therefore, TIMP-1 may not be an ideal biomarker for periodontal diagnosis but may be useful in treatment monitoring of the disease.\",\"PeriodicalId\":56569,\"journal\":{\"name\":\"口腔学期刊(英文)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"口腔学期刊(英文)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4236/OJST.2021.115017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"口腔学期刊(英文)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4236/OJST.2021.115017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impact of Non-Surgical Periodontal Therapy on the Salivary Levels of Tissue Inhibitor of Metalloproteinse-1 (TIMP-1) in Patients with Chronic Periodontitis: A Third World Experience
Chronic periodontitis is a disease of public health concern due to its high prevalence globally, especially in the elderly. The aim of this study was to determine the impact of non-surgical periodontal therapy on salivary levels of TIMP-1 among patients with chronic periodontitis in Nigeria. In this experimental study, unstimulated whole saliva (2 mL) was collected from participants in the experimental and control groups, coded (SP1-40 and SH1-40) respectively and assays for salivary TIMP-1as well as clinical measurements such as plaque (PI), probing depths (PD), and CAL were recorded before and 4 weeks after periodontal treatment. Assay was done using Quantikine human TIMP-1 ELISA kit. Data were presented using frequency tables, means and standard deviation. Paired-T Test assessed association between salivary TIMP-1 before and after treatment. Pearson correlation coefficient was used to correlate salivary TIMP-1 levels with clinical parameters of periodontal disease and levels of statistical significance were set at p < 0.05. A total of 80 respondents participated in the study of which 43.80% were females. Age range was 18 - 60 years with a mean of 35.8 ± 12.46 years. Salivary TIMP-1 levels were lower in the case group (13.58 ± 6.53 ng/mL) than the control (15.27 ± 6.10 ng/mL) at baseline but this was not statistically significant (p = 0.13). There was a statistically significant increase in the salivary levels of TIMP-1 in the case group after phase-one periodontal therapy from 13.58 ± 6.53 ng/mL to 17.24 ± 8.44 ng/mL (p = 0.001). Negative correlations were observed between TIMP-1 and clinical parameters of periodontitis. This was not statistically significant. Therefore, TIMP-1 may not be an ideal biomarker for periodontal diagnosis but may be useful in treatment monitoring of the disease.