2 - ((4-Amino-5 - ((2, 4-dichlorophenoxy)甲基)4 h, 2, 4-triazol-3-yl)含硫的)1 - (5-methyl-1 - (4-nitrophenyl)的h - 1, 2, 3-triazol-4-yl) ethan-1-one

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-09-06 DOI:10.3390/m1720

Bakr F. Abdel-Wahab, A. Mabied, James C. Fettinger, A. Farahat

引用次数: 0

摘要

2-bromo-1的反应(5-methyl-1 (4-nitrophenyl)的h - 1, 2, 3-triazol-4-yl) ethan-1-one 4-amino-5(1)——((2,4-dichlorophenoxy)甲基)4 h, 2, 4-triazole-3-thiol(2)绝对乙醇在催化剂三乙基胺的存在给了2 - ((4-amino-5 - ((2, 4-dichlorophenoxy)甲基)4 h, 2, 4-triazol-3-yl)含硫的)1 - (5-methyl-1 - (4-nitrophenyl)的h - 1, 2, 3-triazol-4-yl) ethan-1-one(3)在73%的收益率。标题杂环(3)的结构通过x射线单晶衍射和波谱分析(核磁共振和红外)得到证实。

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2-((4-Amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one

The reaction of 2-bromo-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (1) with 4-amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazole-3-thiol (2) in absolute ethanol in the presence of triethyl amine as catalyst gave 2-((4-amino-5-((2,4-dichlorophenoxy)methyl)-4H-1,2,4-triazol-3-yl)thio)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)ethan-1-one (3) in 73% yield. The structure of the title heterocycle (3) was confirmed by X-ray single crystal diffraction and spectral analyses (NMR and IR).

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)